Philadelphia University + Thomas Jefferson University

MD/PhD Program
Our Team


Administration

Scott A. Waldman MD, PhD, FCP

Scott A. Waldman MD, PhD, FCP

Dr. Scott Waldman, the MD/PhD Program Director, is Professor and Chair of the Department of Pharmacology and Experimental Therapeutics. His research focuses on GCC, demonstrating the importance of this receptor as a novel tumor suppressor central to the induction of colorectal cancer, and the translation of those observations to patient care.  Indeed, he is the PI of NCI multi-institutional clinical trials examining the utility of GCC as a molecular marker for managing patients with, and as a target for the prevention of, colorectal cancer.  Projects in his laboratory examine the translation of GCC biology into approaches to image colorectal tumors, prevent neoplastic transformation in intestine, and paradigms for vaccine development for patients with colorectal cancer.  His research combines both basic and clinical investigation and serves as an exemplar of translational research. Dr. Waldman’s office is 901 College. 

Phone: 215-955-6086
E-mail: Scott.Waldman@jefferson.edu

Manuel Covarrubias, MD, PhD

Manuel Covarrubias, PhD

Dr. Manuel Covarrubias, the MD/PhD Program Co-director, is Professor in the Department of Neuroscience and member of the Vickie and Jack Farber Institute for Neuroscience. Dr. Covarrubias’ major research interests concern two areas: 1) molecular mechanisms underlying pain sensitization induced by spinal cord injury; and 2) molecular mechanisms of general anesthesia. In the first area, his laboratory has identified a specific potassium channel as a major regulator of excitability in the peripheral pain pathway. This finding is the basis of efforts to investigate novel therapeutic targets to treat neuropathic pain. In the second area, his team has discovered sites of general anesthetic action in voltage-gated ion channels that govern the brain’s electrical activity. Further work in this area will promote the development of more effective and less toxic general anesthetics. Dr. Covarrubias collaborates with researchers from major universities in Philadelphia as well as universities and companies overseas. His research has been supported by the National Institutes of Health for more than 20 years. Dr. Covarrubias office is JHN 416.

Phone: 215-503-4341
E-mail: Manuel.Covarrubias@jefferson.edu

Joanne Balitzky

Joanne Balitzky

Joanne Balitzky is the MD/PhD Administrative Director.  Her office is 910 BLSB. Joanne can be reached by phone at (215) 503-6687 and by email at Joanne.Balitzky@jefferson.edu

Administrative oversight for the Program is provided by the MD/PhD Steering Committee, chaired by Dr. Gerald Grunwald, Dean of the Jefferson College of Biomedical Sciences and Professor of Pathology, Anatomy & Cell Biology, and is composed of faculty who represent seven departments involved in the scientific and/or clinical training of MD/PhD students.  There are also two student representatives to this committee, elected officers of the Jefferson Physician Scientist Association.

Phone: 215-503-6687
E-mail: Joanne.Balitzky@jefferson.edu

Program Faculty

Clicking on the faculty member's name will take you their Profile page for more information regarding their area of research.

Emad  S. Alnemri, PhD

Emad S. Alnemri, PhD
Professor, Biochemistry & Molecular Biology

Molecular mechanisms of apoptosis; Role of inflammation in cancer

Andrew E. Aplin, PhD

Andrew E. Aplin, PhD
Professor, Cancer Biology

Mutant B-RAF and integrin signaling in melanoma 

Jeffrey  L. Benovic, PhD

Jeffrey L. Benovic, PhD
Professor, Biochemistry & Molecular Biology

Dysregulation of G protein signaling in cancer

jrb006

Jonathan R. Brody, PhD
Assistant Professor, Surgery

Dysregulation of G protein signaling in cancer

Bruno Calabretta, MD, PhD

Bruno Calabretta, MD, PhD
Professor, Cancer Biology
Molecular Biology and Gene Regulation

Molecular mechanisms of normal hematopoiesis and BCR/ABL-dependent leukemogenesis

Gino Cingolani, PhD

Gino Cingolani, PhD
Associate Professor, Biochemistry & Molecular Biology

Nucleocytoplasmic transport; Virus assembly; Multisubunit ATPases; Structural and biophysical techniques

Manuel L. Covarrubias, MD, PhD

Manuel L. Covarrubias, MD, PhD
Professor, Neuroscience

Function, structure and pharmacology of voltage-gated ion channels in excitable tissues

Matthew Dalva, PhD

Matthew Dalva, PhD
Associate Professor, Neuroscience

Basic aspects of neural function - the formation of synaptic contacts

Christine Eischen, PhD

Christine Eischen, PhD
Professor, Cancer Biology 

Identification and study of genes that regulate cellular transformation and tumor development.

 

Andrzej Fertala, PhD

Andrzej Fertala, PhD
Professor, Orthopaedic Surgery

Heritable diseases of connective tissues

 	D. Craig Hooper, PhD

D. Craig Hooper, PhD
Professor, Cancer Biology

Neuroimmunology and viral infections

Lorraine Iacovitti, PhD

Lorraine Iacovitti, PhD
Professor, Neuroscience

Stem cells to study and treat Parkinson's disease; Neuroprotective agents to treat Parkinson's Disease; Stem cells to treat stroke; Sites of adult stem cells in brain

Renato V. Iozzo, MD

Renato V. Iozzo, MD
Professor, Pathology, Anatomy & Cell Biology

Proteoglycan control of cancer growth and angiogenesis; Tumor microenvironment and regulation of receptor tyrosine kinases by matrix molecules

Caleb B. Kallen, MD, PhD

Caleb B. Kallen, MD, PhD
Associate Professor, Department of Obstetrics & Gynecology

Our lab is investigating the role of mRNA-binding proteins in obesity-related inflammatory processes with a focus on insulin sensitivity and atherosclerosis

Karen E. Knudsen, PhD

Karen E. Knudsen, PhD
Professor and Chair, Cancer Biology

Hormone signaling in the male reproductive tract; Impact of androgen receptor function on prostate development and disease

Lucia Languino, PhD

Lucia Languino, PhD
Professor, Cancer Biology

Integrin signaling in cancer progression

o	Angelo Lepore, PhD

Angelo Lepore, PhD
Associate Professor, Neuroscience

In vivo role played by astrocyte glutamate transporters in the etiology and treatment of traumatic spinal cord injury (SCI)

 

Le Ma, PhD

Le Ma, PhD
Associate Professor, Neuroscience

Neural networks; molecular pathways involved in branching; cell biological regulation of branching; contribution of branching to circuit function and repair

Alexander Mazo, PhD

Alexander Mazo, PhD
Professor, Biochemistry & Molecular Biology

Epigenetic function of Drosophila ortholog of the MLL oncogene

James P. McGettigan, PhD

James P. McGettigan, PhD
Assistant Professor, Microbiology & Immunology

Investigating vaccine-induced T and B cell responses against viral infections

Steven E. McKenzie, MD, PhD

Steven E. McKenzie, MD, PhD
Professor, Medicine

Platelet biology and genetics

Steven B. McMahon, PhD

Steven B. McMahon, PhD
Professor and Chair, Biochemistry & Molecular Biology

Deregulation of the p53 and MYC transcription networks drivi

A. Sue Menko, PhD

A. Sue Menko, PhD
Professor, Pathology, Anatomy & Cell Biology

Signaling mediating acquisition of the differentiated cell phenotype; Cell adhesion and the cytoskeleton in regulating tissue morphogenesis, regeneration, and fibrosis

Diane E. Merry, PhD

Diane E. Merry, PhD
Professor, Biochemistry & Molecular Biology

Molecular determinants of androgen receptor metabolism and of polyglutamine-expanded androgen receptor misfolding and aggregation

Ulhas Naik, PhD

Ulhas Naik, PhD
Professor, Medicine, Division of Hematology

Molecular mechanisms of cardiovascular diseases and cancer; the role of cell-cell interactions and cell-extracellular matrix interactions

 

fmp004

Fabienne M. Paumet, PhD
Associate Professor, Microbiology & Immunology

Role of phagocytosis in the pathogenesis of infectious diseases; Role of phagocytosis in mast cell function in allergy

Steven E. McKenzie, MD, PhD

Raymond B. Penn, PhD
Professor, Medicine

Identification of cellular and molecular mechanisms by which G protein-coupled receptors (GPCRs) mediate important functions in airway cells and in the lung

Nancy J. Philp

Nancy J. Philp, PhD
Associate Professor, Pathology, Anatomy, & Cell Biology

Monocarboxylate transporters; CD 147; retinal pigment epithelium; retinal metabolism; glycolysis, and JAM-C

Isidore Rigoutsos, PhD

Isidore Rigoutsos, PhD
Professor, Pathology, Anatomy & Cell Biology, Center for Computational Medicine

Computational medicine; microRNAs; tRNAs; piRNAs; post-transcriptional regulatory processes; diagnostics; therapeutics; genomics; big data; pattern/motif discovery; high performance computing; microbial genomics; metagenomics

Makarand V. Risbud, PhD

Makarand V. Risbud, PhD
Professor, Orthopaedic Surgery

Intervertebral disc biology; Hypoxic tissue niches; Stem cell biology; Tissue engineering and regenerative medicine

Ulrich Rodeck, MD, PhD

Ulrich Rodeck, MD, PhD
Professor, Dermatology & Cutaneous Biology

Signal transduction pathways regulating epithelial cell death and survival; specifically, coordinated signaling by receptor tyrosine kinases and integrins as it relates to the inappropriate survival of tumor cells

 

Abdolmohamad Rostami, MD, PhD

Abdolmohamad Rostami, MD, PhD
Professor and Chair, Neurology

Helper T cell subsets and their cytokines in the pathogenesis of autoimmune encephalomyelitis (EAE) and multiple sclerosis; Effect of Bowman-Birk serine protease inhibitor on course of EAE; Mechanisms of intravenous tolerance in EAE; Effects of interleukin-27 (IL-27) on human auto-aggressive
T cells

Jay S. Schneider, PhD

Jay S. Schneider, PhD
Professor, Pathology, Anatomy & Cell Biology

Parkinson's disease; Heavy metal neurotoxicity

Matthias J. Schnell, PhD

Matthias J. Schnell, PhD
Professor and Chair, Microbiology & Immunology
Professor, Biochemistry & Molecular Biology

Development of novel vaccines and viral pathogenesis

Irving M. Shapiro, PhD

Irving M. Shapiro, PhD
Professor, Orthopaedic Surgery

Chondrocyte apoptosis and autophagy; Stem cell function in the intervertebral disc; Development of methods to attach bioactive substances to metals utilized for orthopaedic implants

Shey-Shing Sheu, PhD

Shey-Shing Sheu, PhD
Professor, Medicine

Knowledge to assist the development and discovery of therapeutic strategies targeting mitochondrial dysfunction that causes disease projection such as cardiac arrythmias and heart failure

Richard Smeyne, PhD

Richard Smeyne, PhD
Professor, Neuroscience

Cell biology of Parkinson’s Disease

 

 

Christopher Snyder, PhD

Christopher Snyder, PhD
Assistant Professor, Microbiology & Immunology

Viral immunology: maintenance of adaptive immunity during chronic infections; T cell responses elicited by cytomegalovirus infection; activation of T cell effector functions by innate signals

Ross Summer, MD

Ross Summer, MD
Associate Professor, Medicine, Pulmonary & Critical Care

Dr Summer's laboratory focuses on lung metabolism and understanding how local and systemic metabolic derangements contribute to the onset and progression of lung diseases.

Yuri K. Sykulev, MD, PhD

Yuri K. Sykulev, MD, PhD
Professor, Microbiology & Immunology

Molecular mechanisms regulating cytotoxic T lymphocyte activity

Davide Trotti, PhD

Davide Trotti, PhD
Professor, Neuroscience

Mechanisms of neurodegeneration in amyotrophic lateral sclerosis

Jouni Uitto, MD, PhD

Jouni Uitto, MD, PhD
Professor and Chair, Dermatology & Cutaneous Biology

Biology of connective tissue related to cutaneous diseases that increase the risk of aggressive squamous cell carcinomas

saw103

Scott A. Waldman, MD, PhD
Professor and Chair, Pharmacology & Experimental Therapeutics

Tumor suppressors and their signaling pathways in GI malignancies; Targeted diagnostics and therapeutics in cancer

Philip B. Wedegaertner, PhD

Philip B. Wedegaertner, PhD
Professor, Biochemistry & Molecular Biology

Heterotrimeric G protein regulation of intracellular trafficking; Role of RhoGEFs in mitosis