Philadelphia University + Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Penn, Raymond B

< Back

Profile

rbp101

Raymond B. Penn, PhD

Contact Dr. Penn

Center for Translational Medicine
1025 Walnut Street, Suite 317
Philadelphia, PA 19107

(215) 955-9982
(215) 503-5731 fax

Medical School

PhD Physiology, Temple University School of Medicine - 1988
MS Ed Education, University of Pennsylvania - 1980
BA History, University of Pennsylvania - 1980

University Appointment

Professor of Medicine
Director, Center for Translational Medicine
Director of Pulmonary Research, Jefferson - Jane & Leonard Korman Lung Center

Professional Societies

American Thoracic Society
American Chemical Society
British Pharmacological Society

Research & Clinical Interests

Airway biology; GPCR biology; Asthma pharmacology; Renal transporter biology; Cancer biology; Asthma, COPD, obstructive and fibrotic lung diseases; Chronic metabolic acidosis

The major focus of my research is to identify cellular and molecular mechanisms by which G protein-coupled receptors (GPCRs) mediate important functions in airway cells. GPCR signaling regulates contractile function, synthesis and release of autocrine factors, and cell growth/survival in various airway cells, including airway smooth muscle (ASM), airway epithelium, lung fibroblasts, and T lymphocytes. Aberrant GPCR signaling or exaggerated presentation of GPCR stimuli can promote ASM hypercontractility, airway remodeling, and ASM hyperplasia/hypertrophy, all of which contribute to the pathogenesis of asthma and COPD. Moreover, GPCRs appear to mediate important mitogenic and survival signaling pathways in cells comprising the tumor microenvironment- including epithelia, fibroblasts, stem cells, and inflammatory cells- rendering them potentially important therapeutic targets in the treatment of cancer. Finally, many GPCR genes possess mutations that alter their expression or function; we are particularly interested in characterizing such altered function and its contribution to disease state or disease therapy.

Publications

Most Recent Peer-Reviewed Publications

  1. Pepducins as a potential treatment strategy for asthma and COPD
  2. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines
  3. New targets for resolution of airway remodeling in obstructive lung diseases [version 1; referees: 2 approved]
  4. Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone
  5. 12facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner
  6. An official American thoracic society research statement: Current challenges facing research and therapeutic advances in airway remodeling
  7. Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones
  8. Phosphodiesterase 4 inhibitors attenuate the asthma phenotype produced by β2-adrenoceptor agonists in phenylethanolamine N-methyltransferase-knockout mice
  9. β2Agonists
  10. Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a
  11. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
  12. Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function
  13. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
  14. A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis
  15. Calcilytics for asthma relief
  16. β-agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent
  17. Far from "disappointing"
  18. Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway
  19. GPCRs and arrestins in Airways: Implications for asthma
  20. Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle