Philadelphia University + Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Rattan, Satish

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Satish C. Rattan, DVM

Contact Dr. Rattan

1025 Walnut Street
College Building, Room 320
Philadelphia, PA 19107

(215) 955-5614
(215) 955-5553 fax

Medical School

DVM, Punjab Agricultural University, Hissar, India - 1968
MS, Pharmacology, University of Houston, TX - 1970


Baylor College of Medicine, Houston, TX
University of Texas, South Western Medical School, Dallas, TX


Professor, Medicine, Thomas Jefferson Univ., Philadelphia, PA, 1989- current
Associate Professor
, Harvard Medical College, Boston, MA, 1988-89
Assistant Professor, Harvard Medical College, Boston, MA, 1981-87
Assistant Professor
, University of Texas Health Science Center, San Antonio, TX, 1978-81

Honors & Awards

Council of Indian Organizations Award for Professors & Academic Excellence, 2006
Janssen Award, for Basic Research in Gastroenterology, 1997
Merit Scholarship, Punjab Agricultural University, Hissar, India, 1964-68

Editorial Board

Journal of Pharmacology & Experimental Therapeutics, 1992-99
American Journal of Physiology, 2010-
American Journal of Physiology, 1992-98
Associate Editor GASTROENTEROLOGY, 1986-89

Other Experience & Professional Experience

Teaching Physiology/Pharmacology to Medical Students, 1978-2002
Chief Org. and Director of Am. Motility Society Meeting, Philadelphia, PA, 1998
Member Appoint. and Promot. Committee, Thomas Jefferson University, 2000-
Member Inst. Animal Care & Use Committee, Thomas Jefferson University, 2004-
Member, NIH Study Section, 2003

Expertise & Research Interests

Dr. Rattan is internationally recognized as an outstanding educator and researcher. He is frequently invited as a visiting Professor. Dr. Rattan has received multiple National and International awards in research and teaching.

In 1997, he received a prestigious Janssen Award for his outstanding basic research in Gastroenterology.

In 2006, he was honored by the Council of Indian Organizations as an outstanding professional.

Dr. Rattan''s research has been continuously funded by the National Institutes of Health.

He has been an Associate Editor of GASTROENTEROLOGY, on editorial board of, and a reviewer for a number of prestigious journals.

Research Interest: Disorders of the internal anal sphincter (IAS) underlie many clinical abnormalities, such as fecal incontinence and constipation, hemorrhoids and anal fissures. Such disorders are of particular importance in the growing population of the elderly. The focus of Dr. Rattan''s research has been on: 1. the nature and role of inhibitory neurotransmitters and mediators; 2. the neural pathways in the rectoanal inhibitory reflex; and 3. the molecular bases underlying myogenic tone in the IAS. Using IAS as the model of tonic smooth muscles, Dr. Rattan''s basic studies have provided major advances in the field of of molecular biology of the smooth muscle. The concepts learnt from his studies are directly applicable in a number of organs in the body. Dr. Rattan''s sudies provide important information on the pathophysiology and therapeutic development of anorectal disorders.


Gastrointestinal Motility Disorders; Internal Anal Sphincter; Neurohumoral Control; Immunocytochemistry; Confocal Microscopy; Nonadrenergic Noncholinergic Neurons; Smooth Muscle Tone and Relaxation; Nitric Oxide; Nitric Oxide Synthase; Carbon Monoxide; Heme Oxygenase; Protein Kinase C; RhoA/Rho Kinase; Receptor Binding; Tissue Cell Culture; Renin-Angiotensin-System; Prostanoids


Most Recent Peer-Reviewed Publications

  1. Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery
  2. In vivo magnetofection: A novel approach for targeted topical delivery of nucleic acids for rectoanal motility disorders
  3. Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone
  4. Review article: pathogenesis and clinical manifestations of gastrointestinal involvement in systemic sclerosis
  5. Ca2+/calmodulin/MLCK pathway initiates, and RhoA/ROCK maintains, the internal anal sphincter smooth muscle tone
  6. Role of muscarinic-3 receptor antibody in systemic sclerosis: Correlation with disease duration and effects of IVIG
  7. Role of microRNAs in gastrointestinal smooth muscle fibrosis and dysfunction: Novel molecular perspectives on the pathophysiology and therapeutic targeting
  8. Association between common variable immunodeficiency and collagenous infiltrative disorders of the gastrointestinal tract: A series of four patients
  9. Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a
  10. Nature of extracellular signal that triggers RhoA/ROCK activation for the basal internal anal sphincter tone in humans
  11. Role of SM22 in the differential regulation of phasic vs. Tonic smooth muscle
  12. Bimodal effect of oxidative stress in internal anal sphincter smooth muscle
  13. Survey of anal sphincter dysfunction using anal manometry in patients with fecal incontinence: a possible guide to therapy
  14. Heme oxygenase-1 upregulation modulates tone and fibroelastic properties of internal anal sphincter
  15. Aging-associated oxidative stress leads to decrease in IAS tone via RhoA/ROCK downregulation
  16. Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer
  17. Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle
  18. Smooth muscle fascicular reorientation is required for esophageal morphogenesis and dependent on Cdo
  19. Smooth muscle-specific myosin phosphatase target subunit 1 (MYPT1): An important piece of the puzzle
  20. Biosynthetic pathways and the role of the mas receptor in the effects of angiotensin-(1-7) in smooth muscles