Philadelphia University + Thomas Jefferson University

Publications

Highlighted Publications

Tao L, Jiao XY, Gao ER, Lau W, Lopez BL, Christopher TA, Rao S, William W, Southan G, Sharma K, Koch WJ, Ma XL. Nitrative Inactivation of Thioredoxin-1 and Its Role in Post-Ischemic Myocardial Apoptosis. Circulation. 2006 Sep 26;114(13):1395-402.


Wang Y, Gao E, Tao L, Lau WB, Yuan Y, Goldstein BJ, Lopez BL, Christopher TA, Tian R, Koch W, Ma XL. AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation. 2009 Feb 17;119(6):835-44.


Yi W, Sun Y, Yuan Y, Lau WB, Zheng Q, Wang X, Wang Y, Shang X, Gao E, Koch WJ, Ma XL. C1q/TNF-Related Protein-3, a Newly Identified Adipokine, Is a Novel Anti-Apoptotic, Pro-Angiogenic, and Cardioprotective Molecule in the Ischemic Mouse Heart. Circulation.  2012 Jun 26;125(25):3159-69.


Sun Y, Yi W, Yuan Y, Lau WB, Yi D, Wang X, Wang Y, Su H, Wang X, Gao E, Koch WJ, Ma XL. C1q/Tumor Necrosis Factor-Related Protein-9, a Novel Adipocyte-Derived Cytokine, Attenuates Adverse Remodeling in the Ischemic Mouse Heart via Protein Kinase A Activation. Circulation. 2013 Sep 10;128(26 Suppl 1):S113-20. doi: 10.1161/CIRCULATIONAHA.112.000010.


Wang Y, Gao E, Lau WB, Wang Y, Liu G, Li JJ, Wang X, Yuan Y, Koch WJ, Ma XL. GRK2-Mediated Desensitization of AdipoR1 in Failing Heart. Circulation. 2015 Apr 21;131(16):1392-404. doi: 10.1161/CIRCULATIONAHA.114.015248. Epub 2015 Feb 18.


Recent Publications

Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart

T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity

Role of adipokines in cardiovascular disease

PPARγ Agonist Ameliorates the Impaired Fluidity of the Myocardial Cell Membrane and Cardiac Injury in Hypercholesterolemic Rats

Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction

Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy

Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing AdipoR1/Caveolin-3/STAT3 signaling in diabetic rats

Adiponectin at physiologically relevant concentrations enhances the vasorelaxative effect of acetylcholine via Cav-1/AdipoR-1 signaling

Plasma IgG antibody against cytomegalovirus but not herpes simplex virus is associated with recurrence of atrial fibrillation after catheter ablation

Cloning and transcriptional activity of the mouse Omi/HtrA2 gene promoter

Reduction of CTRP9, a novel anti-platelet adipokine, contributes to abnormal platelet activity in diabetic animals

Preparation and biological activity of the monoclonal antibody against the second extracellular loop of the angiotensin II type 1 receptor

High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation

Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses

Pro-arrhythmic action of autoantibodies against the second extracellular loop of β<inf>1</inf>-adrenoceptor and its underlying molecular mechanisms

Trans-system mechanisms against ischemic myocardial injury

G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart

C1q-TNF-related protein-9, a novel cardioprotetcive cardiokine, requires proteolytic cleavage to generate a biologically active globular domain isoform

AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings

Activation of κ-opioid receptor exerts the glucose-homeostatic effect in streptozotocin-induced diabetic mice