Philadelphia University + Thomas Jefferson University

Publications

Highlighted Publications

Kang JY, Wu C, Tracy J, Lorenzo M, Evans J, Nei M, Skidmore C, Mintzer S, Sharan AD, Sperling MR. Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy. Epilepsia. 2016 Feb;57(2):325-34.

Laser interstitial thermal therapy has emerged as a promising minimally-invasive alternative for the surgical treatment of epilepsy. In our early experience with 20 patients, we achieved 53% seizure freedom at 6 months and preservation of verbal memory after laser ablation. This study is the first to report on the effect of laser therapy not only seizure outcomes, but also on memory.

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Wu C, Boorman DW, Gorniak RJ, Farrell CJ, Evans JJ, Sharan AD. The effects of anatomic variations on stereotactic laser amygdalohippocampectomy and a proposed protocol for trajectory planning. Neurosurgery. 2015 Jun;11 Suppl 1:345-57.

Laser interstitial thermal therapy has emerged as a promising minimally-invasive alternative for the surgical treatment of epilepsy. I have worked to improve and describe surgical techniques to optimize the safety and efficacy of this technology.  In doing so, we have been able to not only achieve more favorable results at our center, but also facilitate laser interstitial thermal therapy at other epilepsy centers.

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Baharoglu MI, Lauric A, Safain MG, Hippelheuser J, Wu C, Malek AM. Widening and High Inclination of the Middle Cerebral Artery Bifurcation are Associated with Presence of Aneurysms. Stroke. 2014 Sep;45(9):2649-55.

In creating a software platform capable of automatically detecting and measuring vascular dimensions and angles, I was able to standardize and facilitate the quantitative analysis of a large number of images.  This tool allowed our group to test the vascular optimality principle, which decrees that minimal energy loss across bifurcations requires optimal caliber control between radii of parent (r0) and daughter branches (r1 and r2): r0(n)=r1(n)+r2(n), with n approximating three.  As a result, we were able to demonstrate that aneurysmal bifurcations, in contrast to non-aneurysmal counterparts, disobey the vascular optimality principle and may exhibit dysregulation in wall sheer stress mediated caliber control.

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Wu C, Evans JJ, Skidmore C, Sperling MR, Sharan AD. Impedance variations over time for a closed-loop neurostimulation device: early experience with chronically implanted electrodes. Neuromodulation. 2013 Jan-Feb;16(1):46-50.

As the field of neuromodulation and the therapeutic implantation of electrodes continue to grow, the need to better understand the electrode-neural interface and the biocompatibility of chronically implanted electrodes becomes more important. The RNS device provides unique long-term data for both intracranial depth and subdural electrodes in human subjects.  In this clinical setting, we found that changes occurring at the electrode-neural interface can affect recordings for up to 20 months after implantation – a finding that all practitioners must consider with all modalities of neuromodulation.

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Recent Publications

Bimodal coupling of ripples and slower oscillations during sleep in patients with focal epilepsy

Intracranial EEG fluctuates over months after implanting electrodes in human brain

Cost-Effectiveness Data Regarding Spinal Cord Stimulation for Low Back Pain

From resection to ablation: A review of resective surgical options for temporal lobe epilepsy and rationale for an ablation-based approach

Longitudinal qualitative characterization of mri features after laser interstitial thermal therapy in drug-resistant epilepsy

Variations in Thalamic Anatomy Affect Targeting in Deep Brain Stimulation for Epilepsy

Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively

Complications of subdural and depth electrodes in 269 patients undergoing 317 procedures for invasive monitoring in epilepsy

Long-Term Pain Reduction Does Not Imply Improved Functional Outcome in Patients Treated With Combined Supraorbital and Occipital Nerve Stimulation for Chronic Migraine

Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy

The effects of anatomic variations on stereotactic laser amygdalohippocampectomy and a proposed protocol for trajectory planning

Endovascular management of cerebral vasospasm following aneurysm rupture: Outcomes and predictors in 116 patients

Deviation from optimal vascular caliber control at middle cerebral artery bifurcations harboring aneurysms

MPTP/MPP+ suppresses activation of protein C in Parkinson's disease

Extraventricular long-axis cannulation of the hippocampus: Technical considerations

Widening and high inclination of the middle cerebral artery bifurcation are associated with presence of aneurysms

Coiling of large and giant aneurysms: Complications and long-term results of 334 cases

A single pipeline embolization device is sufficient for treatment of intracranial aneurysms

Radiosurgery for the treatment of dominant hemisphere periventricular heterotopia and intractable epilepsy in a series of three patients

Neurostimulation for the treatment of epilepsy: A review of current surgical interventions