Philadelphia University + Thomas Jefferson University


Highlighted Publications

Kang JY, Wu C, Tracy J, Lorenzo M, Evans J, Nei M, Skidmore C, Mintzer S, Sharan AD, Sperling MR. Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy. Epilepsia. 2016 Feb;57(2):325-34.

Laser interstitial thermal therapy has emerged as a promising minimally-invasive alternative for the surgical treatment of epilepsy. In our early experience with 20 patients, we achieved 53% seizure freedom at 6 months and preservation of verbal memory after laser ablation. This study is the first to report on the effect of laser therapy not only seizure outcomes, but also on memory.

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Wu C, Boorman DW, Gorniak RJ, Farrell CJ, Evans JJ, Sharan AD. The effects of anatomic variations on stereotactic laser amygdalohippocampectomy and a proposed protocol for trajectory planning. Neurosurgery. 2015 Jun;11 Suppl 1:345-57.

Laser interstitial thermal therapy has emerged as a promising minimally-invasive alternative for the surgical treatment of epilepsy. I have worked to improve and describe surgical techniques to optimize the safety and efficacy of this technology.  In doing so, we have been able to not only achieve more favorable results at our center, but also facilitate laser interstitial thermal therapy at other epilepsy centers.

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Baharoglu MI, Lauric A, Safain MG, Hippelheuser J, Wu C, Malek AM. Widening and High Inclination of the Middle Cerebral Artery Bifurcation are Associated with Presence of Aneurysms. Stroke. 2014 Sep;45(9):2649-55.

In creating a software platform capable of automatically detecting and measuring vascular dimensions and angles, I was able to standardize and facilitate the quantitative analysis of a large number of images.  This tool allowed our group to test the vascular optimality principle, which decrees that minimal energy loss across bifurcations requires optimal caliber control between radii of parent (r0) and daughter branches (r1 and r2): r0(n)=r1(n)+r2(n), with n approximating three.  As a result, we were able to demonstrate that aneurysmal bifurcations, in contrast to non-aneurysmal counterparts, disobey the vascular optimality principle and may exhibit dysregulation in wall sheer stress mediated caliber control.

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Wu C, Evans JJ, Skidmore C, Sperling MR, Sharan AD. Impedance variations over time for a closed-loop neurostimulation device: early experience with chronically implanted electrodes. Neuromodulation. 2013 Jan-Feb;16(1):46-50.

As the field of neuromodulation and the therapeutic implantation of electrodes continue to grow, the need to better understand the electrode-neural interface and the biocompatibility of chronically implanted electrodes becomes more important. The RNS device provides unique long-term data for both intracranial depth and subdural electrodes in human subjects.  In this clinical setting, we found that changes occurring at the electrode-neural interface can affect recordings for up to 20 months after implantation – a finding that all practitioners must consider with all modalities of neuromodulation.

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Recent Publications

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