Philadelphia University + Thomas Jefferson University

Sigal Laboratory

Ectromelia virus expressing green fluorescent protein

The lymph node of a mouse infected in the footpad three days earlier with ectromelia virus expressing green fluorescent protein. The lymph node was stained with antibody to the B-cell marker B220. The image suggests that ectromelia virus is mostly excluded from B cell areas.

Description

Research in my laboratory revolves around viral immunology and pathogenesis. While during my career I have worked and published papers using multiple viruses (foot-and-mouth disease virus, influenza virus, poliovirus, Lymphocytic choriomeningitis, vaccinia virus), during the last decade, one of our major interests has been to study the immunobiology and pathogenesis of ectromelia virus (ECTV), which causes mousepox, the mouse homolog of human smallpox. ECTV is an outstanding model to study acute viral infections as they spread in their biological host following infection through a natural route. Many of our ECTV papers have been published in high impact journals such as Immunity, Cell Host & Microbe, J. Exp Med, PNAS, PLoS Pathogens, and others. These papers identified some of the mechanisms whereby various components of the immune response protect from mousepox including Type I and II interferons, NFkB­­ signaling, natural killer cells, CD8 T-cells, helper and cytolytic CD4 T-cells, and B lymphocytes. Some of these papers also addressed the role of viral immune evasion proteins that counteract various immune mechanisms of resistance to viral disease. Another interest of my laboratory is to use viruses as tools to combat cancer, at this time we are focusing on ovarian cancer.

 

Sigal

Luis Sigal, DMV, PhD
Associate Professor

Contact Dr. Sigal

233 South Tenth Street
Bluemle Life Sciences Building
Room 709
Philadelphia, PA 19107

(215) 503-4535