Philadelphia University + Thomas Jefferson University

Team

Our Team

Vedavathi Madhu

Vedavathi Madhu, PhD
Post-doctoral Fellow

Contact Dr. Madhu

Role of HIF-PHD regulatory network in degenerative disc disease.

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063

He-Hai Pan

He-Hai Pan, MD
Research Fellow

Contact Dr. Pan

My project is to investigate the role of HuR in NP cells in response to hypoxia.

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063

Zariel Johnson

Zariel Johnson, BS
PhD Student

Contact Zariel Johnson

My thesis research investigates the broader functions of the osmo-responsive transcription factor TonEBP in NP cells, using RNA-sequencing paired with in vivo murine models.

 

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063

Hyowon Choi

Hyowon Choi, BA
MD/PhD Student

Contact Hyowon Choi

My thesis project involves understanding the regulatory mechanism of autophagy in NP cells, and determining its role in pathophysiology of degenerative disc disease.

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063

Elizabeth Silagi

Elizabeth Silagi, BS
PhD Student

Contact Elizabeth Silagi

The goal of my thesis research is to understand how the hypoxic and nutrient-limited environment in the IVD affects metabolism and pH regulation in NP cells. My studies involve murine models and metabolomics.

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063

Alexandra Doolittle

Alexandra Doolittle, MS
PhD Student

Contact Alexandra Doolittle

My thesis explores the osmo-regulatory role of TonEBP in NP cells.

 

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063

Deborah Gorth

Deborah Gorth, BS, MS
MD/PhD Student

Contact Deborah Gorth

My thesis explores the underlying mechanisms of disc degeneration using novel in vitro and in vivo models.

 

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063

Carmen Acosta

Carmen Acosta, BS
MS Student

Contact Carmen Acosta

My project focuses on the role of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) in mediating inflammatory pathway in nucleus pulposus cells.

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063

Rouzana Khayat

Rouzana Khayat, BS
MS Student

Contact Rouzana Khayat

My thesis research is on the effect of hypoxia and the role of Hypoxia Inducible Factor -1a (HIF-1a) on OGA and OGT activity in nucleus pulposus (NP) cells.

 

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063

Steven Tessier

Steven Tessier, BS
MS Student

Contact Steven Tessier

I’m involved in characterizing a mouse model of spontaneous disc degeneration, and investigating the mechanisms by which nucleus pulposus cells modulate inflammation through post-translational modification of NFκB.

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063

Emanuel Novais

Emanuel José Magalhães Novais 
MD/PhD Student

Contact Emanuel Novais

My PhD project investigates contribution of ER stress and senescence pathways to disc degenreation using various mouse models and in vitro approaches.

1025 Walnut Street
College Building
Suite 511
Philadelphia, PA 19107

215-955-1063