Philadelphia University + Thomas Jefferson University

Publications

Highlighted Publications

Afonso DJS, Liu D, Machado DR, Pan H, Jepson JEC, Rogulja D, Koh K. (2015). TARANIS functions with Cyclin A and Cdk1 in a novel arousal center to control sleep in Drosophila. Current Biology. 25:1717-26. [Highlighted in the Editors' Choice section of Science Signaling.

We identify Taranis as a novel sleep-promoting factor. Taranis controls sleep amount by regulating CycA protein levels and inhibiting Cdk1 activity in a novel arousal center.  (PDF: Koh Taranis CB 2015 Suppl)


Jepson JEC, Shahidullah M, Liu D, le Marchand S, Liu S, Wu MN, Levitan IB, Dalva MB, Koh K. (2014). Regulation of synaptic development and function by the Drosophila PDZ protein DYSCHRONIC. Development. 141:4548-57.

We define novel presynaptic roles for the Dyschronic scaffold protein in synapse morphology, active zone size and neurotransmission.


Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont J, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K*, Wu MN*. (2014). WIDE AWAKE mediates the circadian timing of sleep onset. Neuron. 82: 151-66. *Co-corresponding authors.

We identify a conserved molecule, Wide Awake, that regulates timing of sleep onset by modulating the excitability of an arousal-promoting circuit based on circadian timing information.


Jepson JEC, Shahiddullah M, Lamaze A, Peterson D, Pan H, Koh K. (2012). dyschronic, a Drosophila homolog of a deaf-blindness gene, regulates circadian output and Slowpoke channels. PLoS Genetics. 8(4):e1002671.

We identify a Drosophila homolog of a deaf-blindness gene as a new component of the circadian output pathway and an important regulator of potassium channel expression.


Wu MN, Joiner WJ, Dean T, Yue Z, Smith CJ, Chen D, Hoshi T, Sehgal A, Koh K. (2010).  SLEEPLESS, a Ly-6/neurotoxin family member, regulates levels, localization, and activity of Shaker. Nature Neuroscience. 13: 69-75. [Evaluated by Faculty of 1000.]

We show that the sleep-promoting factor Sleepless, which is predicted to belong to the Ly-6/neurotoxin family, regulates levels, localization, and activity of the Shaker potassium channel.


Recent Publications

Identification of octopaminergic neurons that modulate sleep suppression by male sex drive

Regulation of sleep plasticity by a thermo-sensitive circuit in Drosophila

Control of sleep by a network of cell cycle genes

TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila

WIDE AWAKE mediates the circadian timing of sleep onset

Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic

Cell-specific fine-tuning of neuronal excitability by differential expression of modulator protein isoforms

Genetic and Anatomical Basis of the Barrier Separating Wakefulness and Anesthetic-Induced Unresponsiveness

Dyschronic, a Drosophila homolog of a deaf-blindness gene, regulates circadian output and slowpoke channels

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant

SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker

The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor

An isoform-specific mutant reveals a role of PDP1ε in the circadian oscillator

The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting

Identification of SLEEPLESS, a sleep-promoting factor

A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila

Molecular analysis of sleep:wake cycles in Drosophila

A Drosophila model for age-associated changes in sleep:wake cycles

JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS

The nT1 translocation separates vulval regulatory elements from the egl-18 and elt-6 GATA factor genes