Overall research goal of the Kirino lab is to understand the biogenesis and molecular function of small non-coding RNAs (ncRNAs), and use the knowledge for the development of novel biomarkers and therapeutic applications in diseases. Small ncRNAs have emerged recently as one of the most novel and exciting areas of gene expression regulation. By taking advantage of RNA biochemistry, molecular/cell biology, and computational biology, the Kirino lab is particularly focused on transfer RNA (tRNA)-derived ncRNAs and PIWI-interacting RNAs (piRNAs), which play important roles in cancer pathogenesis and germline development, respectively. Recent studies of the lab discovered that a novel type of tRNA halves, termed SHOT-RNAs, actively spur cell proliferation in breast and prostate cancers, suggesting a new role for tRNA and a possible target for a new class of therapy. Dr. Kirino is Faculty member (Principal Investigator) of Computational Medicine Center and Assistant Professor in Department of Biochemistry and Molecular Biology at Thomas Jefferson University where he joined in mid-2013. Prior to joining TJU, Dr. Kirino was Assistant Professor in Department of Biomedical Sciences at Cedars Sinai Medical Center (2010-2013). Dr. Kirino received his BSc (2001), MSc (2003) and PhD (2006) from The University of Tokyo (Dr. Tsutomu Suzuki’s lab) and performed Postdoc study (2006-2010) in University of Pennsylvania (Dr. Zissimos Mourelatos’ lab).
Computational Medicine Center
Department of Biochemistry and Molecular Biology
Jefferson Alumni Hall
1020 Locust Street
Suite M77 office | Suite 230C-D lab
Philadelphia, PA 19107