Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA, Littman DR, Huh JR. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016 Feb 26; 351(6276): 933-9. PMID: 26822608; PMCID:PMC4782964; DOI:10.1126/science.aad0314.
This paper describes that material immune activation during pregnancy can induce autisms spectrum disorder in offspring and that it is dependent on RORgt and interleukin-17A expression.
Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo FW, Meadows S, Montoya NR, Herrera N, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR. DDX5 and its associated lncRNA Rmrp modulate Th17 cell effector functions. Nature. 2015 Dec 24; 528(7583): 517-22. PMID: 26675721; PMCID: PMC4762670; DOI: 10.1038/nature16193.
This paper describes the RNA helicase DEAD-box protein 5 (DDX5) and nuclear long noncoding RNA, Rmrp as binding partners for RORgt, and showed that their complex formation is required for RORgt-dependent transcriptional activation and Th17 differentiation.
Longman RS, Yang Y, Diehl GE, Kim SV, Littman DR. Microbiota: Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity. Cold Spring Harbor Symposia on Quantitative Biology. 2013; 78:193-201. PMID: 24913313; PMCID: PMC4367195 DOI: 10.1101/sqb.2013.78.020081.
This review paper describes how microbiota contributes to compartmentalization of host immune responses and its impact in T cell-mediated, organ-specific autoimmune diseases.
Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin DB, Xu R, Littman DR. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science. 2013. June 21; 340 (6139): 1456-9. PMID: 23661644; PMCID: PMC3762262; DOI: 10.1126/science.1237013.
This paper describes for the first time T cell homing receptor for the large intestine, GPR15 and its role in local enrichment of regulatory T cells to maintain immune homeostasis in the large intestine.
Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka R, Chow J, Manel N, Ciofani, MC, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR. Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORgt activity. Nature. 2011 April 28; 472(7344): 486-90. PMID: 21441909; PMCID: PMC3172133; DOI:10.1038/nature09978.
This paper describes the identification of Digoxin and its derivatives as novel RORgt inhibitors, and showed that they can suppress Th17 cell differentiation.
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