Philadelphia University + Thomas Jefferson University

Astrof Laboratory



Congenital heart disease is among the most prevalent forms of human birth defects. Our lab seeks to understand the mechanisms regulating the development of the cardiovascular system and the processes that go awry in congenital heart disease.  We are using genetics, cell biology and 3-dimensional imaging to uncover signaling pathways mediating intercellular communications between distinct populations of progenitors regulating morphogenesis of the heart and associated blood vessels.





Sophie Astrof, PhD
Associate Professor

Contact Dr. Astrof

1020 Locust Street
543F JAH
Philadelphia, PA 19107

(215) 955-9982