Philadelphia University + Thomas Jefferson University

Approved Department of Urology Clinical Trials

07F.202:    Prostate Cancer Prevention

Purpose:   To evaluate the safety and efficacy of Polyphenol E, found in green tea, in preventing progression of High Grade PIN (diagnosed from prostate biopsy) to prostate cancer

Title:  Phase II, Randomized, Double-blind, Multi-center Study of Polyphenol E in Men with High Grade Prostatic Intraepithelial Neoplasia (HGPIN)

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06F.145:    Prostate Cancer Detection

Purpose:  A research study to see if treatment with a drug that can reduce blood flow in the prostate will help to improve detection of prostate cancer in patients scheduled for prostate biopsy, aided by ultrasound imaging with a contrast (dye) agent. 

Title:  US Prostate Cancer Detection with Dutasteride Pretreatment (NIH Grant #1R01CA118003-01A1).

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06C.342 :    Prostate Cancer Treatment

Purpose:  HIFU - High Intensity Focused Ultrasound - The purpose of this research study is to measure the safety and effectiveness of the Ablatherm Integrated Imaging for the treatment of low risk prostate cancer by using ultrasound waves traveling through the rectal wall focused on the prostate gland.

Title:  Ablatherm Integrated Imaging High Intensity Focused Ultrasound (HIFU) for the Treatment of Low Risk, Localized Prostate Cancer

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07C.303 :    Prostate Cancer Treatment

Purpose:  To test the safety and effectiveness of a drug called Advodart (dutasteride) in combination with Casodex, compared to placebo and Casodex in further reducing the progression of prostate cancer and delaying the need for more aggressive treatment (i.e. chemotherapy).

Title:  A Randomized, Double-blinded, Parallel Group Study Comparing Casodex 50mg plus Placebo to Casodex 50mg plus dutasteride 3.5mg Administered for 18 months to Men with Prostate Cancer Who Have Failed First-Line Androgen Deprivation Therapy (Assessed by Rising PSA) Followed by a Two-Year Extension Phase

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06C.316 :    Over Active Bladder –Spinal Cord Injured  and MS Patients

Purpose: The purpose of this study is to assess the safety and effectiveness of botulinum toxin type A in treating overactive bladder in spinal cord or multiple sclerosis patients.

Title: A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Safety and Efficacy of Repeat Treatment with Two Dose Levels of BOTOX® (Botulinum Toxin Type A) Purified Neurotoxin Complex Followed by a Treatment with BOTOX® in Patients With Urinary Incontinence Due to Neurogenic Detrusor Overactivity      

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