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Maurizio Pacifici, PhD

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Most Recent Peer-reviewed Publications

  1. Hereditary multiple exostoses: are there new plausible treatment strategies?
  2. Acquired and congenital forms of heterotopic ossification: new pathogenic insights and therapeutic opportunities
  3. Retinoid roles and action in skeletal development and growth provide the rationale for an ongoing heterotopic ossification prevention trial
  4. Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilage
  5. Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model
  6. Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference
  7. The pathogenic roles of heparan sulfate deficiency in hereditary multiple exostoses
  8. Heparan sulfate antagonism alters bone morphogenetic protein signaling and receptor dynamics, suggesting a mechanism in hereditary multiple exostoses
  9. Hereditary Multiple Exostoses: New Insights into Pathogenesis, Clinical Complications, and Potential Treatments
  10. Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs
  11. Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation
  12. Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice
  13. Epiprofin Regulates Enamel Formation and Tooth Morphogenesis by Controlling Epithelial-Mesenchymal Interactions During Tooth Development
  14. Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in hereditary multiple exostoses
  15. Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent
  16. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1R206HFibrodysplasia Ossificans Progressiva (FOP) Mutation
  17. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model
  18. HhAntag, a Hedgehog Signaling Antagonist, Suppresses Chondrogenesis and Modulates Canonical and Non-Canonical BMP Signaling
  19. Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling
  20. Excess BMP Signaling in Heterotopic Cartilage Forming in Prg4 -null TMJ Discs