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Maurizio Pacifici, PhD

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Most Recent Peer-reviewed Publications

  1. Advances in the pathogenesis and possible treatments for multiple hereditary exostoses from the 2016 international MHE conference
  2. The pathogenic roles of heparan sulfate deficiency in hereditary multiple exostoses
  3. Hereditary Multiple Exostoses: New Insights into Pathogenesis, Clinical Complications, and Potential Treatments
  4. Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs
  5. Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation
  6. Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice
  7. Epiprofin Regulates Enamel Formation and Tooth Morphogenesis by Controlling Epithelial-Mesenchymal Interactions During Tooth Development
  8. Retinoid roles and action in skeletal development and growth provide the rationale for an ongoing heterotopic ossification prevention trial
  9. Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in hereditary multiple exostoses
  10. Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent
  11. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1R206HFibrodysplasia Ossificans Progressiva (FOP) Mutation
  12. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model
  13. HhAntag, a Hedgehog Signaling Antagonist, Suppresses Chondrogenesis and Modulates Canonical and Non-Canonical BMP Signaling
  14. Osteophyte formation and matrix mineralization in a TMJ osteoarthritis mouse model are associated with ectopic hedgehog signaling
  15. Excess BMP Signaling in Heterotopic Cartilage Forming in Prg4 -null TMJ Discs
  16. Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders
  17. Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs
  18. Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg
  19. Articular Cartilage: Structural and Developmental Intricacies and Questions
  20. Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: Mechanisms and mysteries