Philadelphia University + Thomas Jefferson University

Corticotropin-Releasing Factor (CRF)-serotonin (5-HT) Interactions

Rita Valentino, PhD

Rita Valentino, PhD
Children's Hospital of Philadelphia
Principal Investigator

Maria Waselus
Graduate Student
Molecular Cell Biology Program

CRF and vGlut1 in the dorsolateral DRNCRF and vGlut1 in the dorsolateral DRN

Goal: To examine interactions between the stress hormone CRF and serotonin (5-HT) in the dorsal raphe nucleus (DRN). Ultrastructural studies examining CRF afferents and their post-synaptic targets in DRN subregions are intended to elucidate the anatomical substrates involved in the regulation of the DRN-5-HT system by CRF.