pxp004

Piera Pasinelli, PhD

Contact Dr. Pasinelli

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 955-8394
(215) 503-4358 fax

Most Recent Peer-reviewed Publications

  1. Blood–Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies
  2. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS
  3. Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene
  4. Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD
  5. Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood–brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis
  6. Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity
  7. Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
  8. ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis
  9. Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis
  10. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization
  11. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death
  12. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate invitro and invivo neuronal death
  13. Defects in synapse structure and function precede motor neuron degeneration in Drosophila models of FUS-related ALS
  14. Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS
  15. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS
  16. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
  17. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2
  18. In vivo and in vitro determination of cell death markers in neurons
  19. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
  20. Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria