mlc105

Manuel Covarrubias, MD, PhD

Contact Dr. Covarrubias

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 503-4340
(215) 503-4358 fax

Most Recent Peer-reviewed Publications

  1. Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors
  2. Regulation of nociceptive glutamatergic signaling by presynaptic Kv3.4 channels in the rat spinal dorsal horn
  3. Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels
  4. Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics
  5. Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons
  6. Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation
  7. A novel bifunctional alkylphenol anesthetic allows characterization of γ-aminobutyric acid, type A (GABAA), receptor subunit binding selectivity in synaptosomes
  8. Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions
  9. Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics
  10. Positive allosteric modulation of Kv channels by sevoflurane: Insights into the structural basis of inhaled anesthetic action
  11. Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition
  12. Kv3.4 channel function and dysfunction in nociceptors
  13. Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury
  14. Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanisms
  15. Dipeptidyl-peptidase-like proteins cast in a new role: Enabling scorpion toxin block of A-type K+ channels
  16. Insight into the modulation of Shaw2 Kv channels by general anesthetics: Structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR
  17. Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels
  18. Novel activation of voltage-gated K+ channels by sevoflurane
  19. Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons
  20. Molecular mapping of general anesthetic sites in a voltage-gated ion channel