Manuel Covarrubias, MD, PhD

Contact Dr. Covarrubias

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 503-4340
(215) 503-4358 fax

University Appointment


Research and Clinical Interests

The research in my laboratory focuses on voltage-gated potassium channels (Kv channels) expressed in the nervous system and the heart. We investigate the molecular mechanisms governing the function and regulation of these ion channels. In particular, we focus on: 1) inactivation gating of Kv channels and its modulation by auxiliary subunits and signaling cascades; 2) structural mapping of inhaled anesthetic/alcohol sites; and 3) functional impact of A-type potassium currents in dorsal root ganglion neurons. These studies can impact our understanding of neuronal plasticity, epilepsy, pain, autism, arrhythmias, anesthesia and alcohol intoxication. Furthermore, they may reveal potential drug-targets. The research platform of our work is based on a modern multidisciplinary approach, which combines electrophysiology, molecular biology, biochemistry, pharmacology and mathematical modeling.