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Luis Sigal, DVM, PhD

Contact Dr. Sigal

233 South Tenth Street
Bluemle Life Sciences Building, Room 709
Philadelphia, PA 19107

(215) 503-4535

Most Recent Peer-reviewed Publications

  1. Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node
  2. Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts
  3. DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death
  4. Activation of CD8 T Lymphocytes during Viral Infections
  5. The Pathogenesis and Immunobiology of Mousepox
  6. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment
  7. Protective CD8+T cell memory without help
  8. CD4+T cell help is dispensable for protective CD8+T cell memory against mousepox virus following vaccinia virus immunization
  9. Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth
  10. Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection
  11. Impact of distinct poxvirus infections on the specificities and functionalities of CD4+T cell responses
  12. MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve toll-like receptor 2
  13. Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection
  14. Immunology: Memory cells sound the alarm
  15. Memory CD8+T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection
  16. Getting in front and behind the enemy lines to counter virus infection
  17. Memory CD8<sup>+</sup> T cell protection
  18. Characterization of ectromelia virus deficient in EVM036, thehomolog of vaccinia virus F13l, and its application for rapid generation of recombinant viruses
  19. Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease
  20. Perforin-dependent CD4+T-cell cytotoxicity contributes to control a murine poxvirus infection