Timothy L. Manser, PhD

Contact Dr. Manser

233 South Tenth Street
Bluemle Life Sciences Building, Room 302
Philadelphia, PA 19107

(215) 503-4672
(215) 923-7145 fax

Most Recent Peer-reviewed Publications

  1. Evaluation of the efficiency of human immune system reconstitution in NSG mice and NSG mice containing a human HLA.A2 transgene using hematopoietic stem cells purified from different sources
  2. Cutting edge: Macrophages are required for localization of antigen-activated b cells to the follicular perimeter and the subsequent germinal center response
  3. A germline-competent embryonic stem cell line from NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice
  4. Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing
  5. Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever
  6. Immunologic research at Thomas Jefferson University: A recent history
  7. Human immune system mice: Current potential and limitations for translational research on human antibody responses
  8. Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments
  9. Expression of cellular FLIP by B cells is required for their participation in an immune response
  10. Germinal center reutilization by newly activated B cells
  11. The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints
  12. Initial Clonal Expansion of Germinal Center B Cells Takes Place at the Perimeter of Follicles
  13. Influence of B cell antigen receptor expression level on pathways of B cell tolerance induction
  14. A role for cFLIP in B cell proliferation and stress MAPK regulation
  15. Specialization and Complementation of Humoral Immune Responses to Infection: Preface
  16. Influence of fas on the regulation of the response of an anti-nuclear antigen B cell clonotype to foreign antigen
  17. Primary development and participation in a foreign antigen-driven immune response of a chromatin-reactive B cell clonotype are not influenced by TLR9 or other MyD88-dependent TLRs
  18. Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production
  19. Quantitatively reduced participation of anti-nuclear antigen B cells that down-regulate B cell receptor during primary development in the germinal center/memory B cell response to foreign antigen
  20. Autoantigen-B cell antigen receptor interactions that regulate expression of B cell antigen receptor loci