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Lucia Languino, PhD

Contact Dr. Languino

Sidney Kimmel Cancer Center
233 S. Tenth Street, Suite 506
Philadelphia, PA 19107

(215) 503-3442

Most Recent Peer-reviewed Publications

  1. Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer
  2. Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors
  3. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer
  4. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes
  5. A neuronal network of mitochondrial dynamics regulates metastasis
  6. Transgenic expression of the mitochondrial chaperone TNFR-associated protein 1 (TRAP1) accelerates prostate cancer development
  7. v-Src oncogene induces Trop2 proteolytic activation via cyclin D1
  8. Exosome-mediated transfer of αvβ3 integrin from tumorigenic to nontumorigenic cells promotes a migratory phenotype
  9. αvβ6 integrin promotes castrate-resistant prostate cancer through JNK1-mediated activation of androgen receptor
  10. Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming
  11. β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation
  12. The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis
  13. CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation
  14. Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma
  15. A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice
  16. Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism
  17. Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1
  18. Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer
  19. PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
  20. Deregulation of MIR-34b/Sox2 predicts prostate cancer progression