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Karen E. Knudsen, PhD

Contact Dr. Knudsen

Sidney Kimmel Cancer Center
233 South 10th Street
BLSB 1050
Philadelphia, PA 19107

(215) 503-5692

Most Recent Peer-reviewed Publications

  1. Detection of activating estrogen receptor gene (ESR1) mutations in single circulating tumor cells
  2. Posttranscriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors
  3. Analysis of circulating cell-free DnA identifies multiclonal heterogeneity of BRCA2 reversion mutations associated with resistance to PARP inhibitors
  4. Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer
  5. PARP Inhibitors in Prostate Cancer
  6. Sigma1 targeting to suppress aberrant androgen receptor signaling in prostate cancer
  7. Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle
  8. Cell cycle-coupled expansion of AR activity promotes cancer progression
  9. Potential Impact on Clinical Decision Making via a Genome-Wide Expression Profiling: A Case Report
  10. There and back again: The middle earth of DNA repair
  11. Linking DNA Damage and Hormone Signaling Pathways in Cancer
  12. Patient-level DNA damage and repair pathway profiles and prognosis after prostatectomy for high-risk prostate cancer
  13. Downregulation of critical oncogenes by the selective SK2 Inhibitor ABC294640 hinders prostate cancer progression
  14. Development and Validation of a Scalable Next-Generation Sequencing System for Assessing Relevant Somatic Variants in Solid Tumors
  15. Novel actions of next-generation taxanes benefit advanced stages of prostate cancer
  16. Models of neuroendocrine prostate cancer
  17. Cell-cycle-dependent regulation of androgen receptor function
  18. Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function
  19. Consequence of the tumor-associated conversion to cyclin D1b
  20. Hormone whodunit: Clues for solving the case of intratumor androgen production