James B. Jaynes, PhD

Contact Dr. Jaynes

1020 Locust Street
Room JAH-479
Philadelphia, PA 19107

(215) 503-4778

Most Recent Peer-reviewed Publications

  1. Using competition assays to quantitatively model cooperative binding by transcription factors and other ligands
  2. Boundaries of loop domains (insulators): Determinants of chromosome form and function in multicellular eukaryotes
  3. Determinants of Chromosome Architecture: Insulator Pairing in cis and in trans
  4. Genome-wide identification of Drosophila Hb9 targets reveals a pivotal role in directing the transcriptome within eight neuronal lineages, including activation of Nitric oxide synthase and Fd59a/Fox-D
  5. The Drosophila eve Insulator Homie Promotes eve Expression and Protects the Adjacent Gene from Repression by Polycomb Spreading
  6. Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired
  7. Regulation of a duplicated locus: Drosophila sloppy paired is replete with functionally overlapping enhancers
  8. Ecdysone- and NO-Mediated Gene Regulation by Competing EcR/Usp and E75A Nuclear Receptors during Drosophila Development
  9. A chromatin insulator mediates transgene homing and very long-range enhancer-promoter communication
  10. The DNA-binding Polycomb-group protein Pleiohomeotic maintains both active and repressed transcriptional states through a single site
  11. The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila
  12. Transcription of bxd Noncoding RNAs Promoted by Trithorax Represses Ubx in cis by Transcriptional Interference
  13. Embryonic even skipped-dependent muscle and heart cell fates are required for normal adult activity, heart function, and lifespan
  14. Erratum: Drawing lines in the sand: Even skipped et al. and parasegment boundaries (Developmental Biology (2004) 269 (609-622) DOI: 10.1016/j.ydbio. 2004.03.001)
  15. Drawing lines in the sand: Even skipped et al. and parasegment boundaries
  16. Embryonic origins of a motor system: Motor dendrites form a myotopic map in Drosophila
  17. Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila
  18. Specification of Motoneuron Fate in Drosophila: Integration of Positive and Negative Transcription Factor Inputs by a Minimal eve Enhancer
  19. Even-skipped, acting as a repressor, regulates axonal projections in Drosophila
  20. Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila