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Ya-ming Hou, PhD

Contact Dr. Hou

233 South 10th Street
220 BLSB
Philadelphia, PA 19107

(215) 503-4480
(215) 923-9162 fax

Most Recent Peer-reviewed Publications

  1. Compound heterozygosity for loss-of-function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation
  2. Effect of Nascent Peptide Steric Bulk on Elongation Kinetics in the Ribosome Exit Tunnel
  3. A genetically encoded fluorescent tRNA is active in live-cell protein synthesis
  4. TrmD: A Methyl Transferase for tRNA Methylation With m1G37
  5. Transcription-Translation coupling: Direct interactions of RNA polymerase with ribosomes and ribosomal subunits
  6. Mg2+regulates transcription of mgtA in Salmonella Typhimurium via translation of proline codons during synthesis of the MgtL peptide
  7. Initiator tRNA genes template the 3' CCA end at high frequencies in bacteria
  8. Methyl transfer by substrate signaling from a knotted protein fold
  9. Molecular basis and consequences of the cytochrome c-tRNA interaction
  10. A novel HSD17B10 mutation impairing the activities of the mitochondrial Rnase P complex causes X-linked intractable epilepsy and neurodevelopmental regression
  11. Kinetic Analysis of tRNA Methyltransferases
  12. Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD
  13. The UGG isoacceptor of tRNAProis naturally prone to frameshifts
  14. Maintenance of protein synthesis reading frame by EF-P and m 1 G37-tRNA
  15. Loss-of-function alanyl-tRNA synthetase mutations cause an autosomal-recessive early-onset epileptic encephalopathy with persistent myelination defect
  16. Post-transcriptional modifications to tRNA - A response to the genetic code degeneracy
  17. Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase
  18. Impaired function is a common feature of neuropathy-associated glycyl-tRNA synthetase mutations
  19. A Divalent Metal Ion-Dependent N1-Methyl Transfer to G37-tRNA
  20. A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys