hbg002

Howard Gamper, Jr., PhD

Contact Dr. Gamper, Jr.

233 S. 10th Street
Philadelphia, PA 19107

(215) 503-9798
(215) 503-4954 fax

Most Recent Peer-reviewed Publications

  1. Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits
  2. Effect of Nascent Peptide Steric Bulk on Elongation Kinetics in the Ribosome Exit Tunnel
  3. A genetically encoded fluorescent tRNA is active in live-cell protein synthesis
  4. A novel HSD17B10 mutation impairing the activities of the mitochondrial Rnase P complex causes X-linked intractable epilepsy and neurodevelopmental regression
  5. The UGG isoacceptor of tRNAProis naturally prone to frameshifts
  6. Maintenance of protein synthesis reading frame by EF-P and m 1 G37-tRNA
  7. Loss-of-function alanyl-tRNA synthetase mutations cause an autosomal-recessive early-onset epileptic encephalopathy with persistent myelination defect
  8. Post-transcriptional modifications to tRNA - A response to the genetic code degeneracy
  9. A Divalent Metal Ion-Dependent N1-Methyl Transfer to G37-tRNA
  10. Amino acid - Dependent stability of the acyl linkage in aminoacyl-tRNA
  11. The selective tRNA aminoacylation mechanism based on a single G.U pair
  12. Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position
  13. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD)
  14. Conservation of structure and mechanism by Trm5 enzymes
  15. Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding
  16. Distinct kinetic determinants for the stepwise CCA addition to tRNA
  17. RecA-mediated strand invasion of DNA by oligonucleotides substituted with 2-aminoadenine and 2-thiothymine
  18. Properties of pseudo-complementary DNA substituted with weakly pairing analogs of guanine or cytosine
  19. Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3′ end
  20. tRNA Integrity Is a Prerequisite for Rapid CCA Addition: Implication for Quality Control