Teresa Fernandes-Alnemri, PhD

Contact Dr. Fernandes-Alnemri

233 S. 10th Street
902 BLSB
Philadelphia, PA 19107

(215) 503-4631

Most Recent Peer-reviewed Publications

  1. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
  2. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
  3. Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4
  4. Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function
  5. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome
  6. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity
  7. Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
  8. Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome
  9. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
  10. A novel role for the mitochondrial HTRA2/OMI protease in aging
  11. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
  12. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection
  13. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
  14. Cutting edge: Mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence
  15. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
  16. Functional consequences of a germline mutation in the leucine-rich repeat domain of NLRP3 Identified in an atypical autoinflammatory disorder
  17. Anti-inflammatory compounds parthenolide and bay 11-7082 are direct inhibitors of the inflammasome
  18. Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
  19. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
  20. Chapter Thirteen Assembly, Purification, and Assay of the Activity of the ASC Pyroptosome