esa101

Emad Alnemri, PhD

Contact Dr. Alnemri

233 S. 10th Street
904 BLSB
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Most Recent Peer-reviewed Publications

  1. The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes
  2. SUMO-mediated regulation of NLRP3 modulates inflammasome activity
  3. Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis article
  4. Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018
  5. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
  6. The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation
  7. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  8. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
  9. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
  10. Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4
  11. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
  12. Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015
  13. Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function
  14. Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy
  15. IKKα negatively regulates ASC-dependent inflammasome activation
  16. Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome
  17. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity
  18. Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
  19. Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome
  20. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging