Philadelphia University + Thomas Jefferson University

Zhang, Jianke

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Jianke Zhang, PhD

Contact Dr. Zhang

233 South 10th Street
Bluemle Life Sciences Building 731
Philadelphia, PA 19107

(215) 503-4559
(215) 503-4558 fax

Research and Clinical Interests

Immune tolerance and homeostasis; lymphocyte apoptosis; cytokine-receptor signal transduction; lymphocyte development; signal transduction mechanisms by the Fas/TNF receptor family members that mediate apoptosis and growth/proliferation; Toll-like receptor signaling; transgenic and gene targeting (knockout) analyses of protein functions in mice.

Publications

Most Recent Peer-Reviewed Publications

  1. Daxx plays a novel role in T cell survival but is dispensable in Fas-induced apoptosis
  2. Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation
  3. Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation
  4. MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome
  5. CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN
  6. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
  7. Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer
  8. Erratum: Phosphorylation of FADD by the kinase CK1α promotes KRASG12Dinduced lung cancer (Science Signaling 8:361 (ra9))
  9. Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer
  10. The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth
  11. RIPK3 takes another deadly turn
  12. Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML
  13. Inhibition of Fas-Associated Death Domain-Containing Protein (FADD) Protects against Myocardial Ischemia/Reperfusion Injury in a Heart Failure Mouse Model
  14. Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T cells and ameliorates experimental autoimmune encephalomyelitis
  15. Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis
  16. Erratum: Functional complementation between FADD and RIP1 in embryos and lymphocytes (Nature (2011) 471 (373-376))
  17. RIP1-mediated regulation of lymphocyte survival and death responses
  18. RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation
  19. Epithelial cell death is an important contributor to oxidant-mediated acute lung injury
  20. Functional complementation between FADD and RIP1 in embryos and lymphocytes