Philadelphia University + Thomas Jefferson University

Walker, Janice L.

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Janice L. Walker, PhD

Janice L. Walker, PhD

Contact Dr. Walker

1020 Locust Street
Jefferson Alumni Hall, Suite 571
Philadelphia, PA 19107

(215) 503-5903

Research and Clinical Interests

The role of unique precursors for the mesenchymal cells involved in injury response and the lens fibrotic disease Posterior Capsule Opacification, the role of mesenchymal cells in directing collective migration/invasion as well as processes critical to cancer cell progression and metastasis.


Most Recent Peer-Reviewed Publications

  1. Cells activated for wound repair have the potential to direct collective invasion of an epithelium
  2. Establishment of a clinically relevant ex vivo mock cataract surgery model for investigating epithelial wound repair in a native microenvironment
  3. A central role for vimentin in regulating repair function during healing of the lens epithelium
  4. Regional-specific alterations in cell-cell junctions, cytoskeletal networks and myosin-mediated mechanical cues coordinate collectivity of movement of epithelial cells in response to injury
  5. The hippo signaling pathway is required for salivary gland development and its dysregulation is associated with sjogren's syndrome
  6. Unique precursors for the mesenchymal cells involved in injury response and fibrosis
  7. Hypoglycosylated E-cadherin promotes the assembly of tight junctions through the recruitment of PP2A to adherens junctions
  8. Overexpression of DPAGT1 leads to aberrant N-glycosylation of E-cadherin and cellular discohesion in oral cancer
  9. Integrins in lens development and disease
  10. Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: Insights into the formation of acinar and ductal structures
  11. γ-Secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung
  12. A Skp2 autoinduction loop and restriction point control
  13. Activation of Src kinases signals induction of posterior capsule opacification
  14. ERK activity and G1 phase progression: Identifying dispensable versus essential activities and primary versus secondary targets
  15. Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts
  16. Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression
  17. Regulation of growth factor signaling and cell cycle progression by cell adhesion and adhesion-dependent changes in cellular tension
  18. Transition between proliferation and differentiation for lens epithelial cells is regulated by Src family kinases
  19. Role for α6 integrin during lens development: Evidence for signaling through IGF-1R and ERK
  20. A signaling role for the uncleaved form of 36 integrin in differentiating lens fiber cells