Philadelphia University + Thomas Jefferson University

Vadigepalli, Rajanikanth

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Rajanikanth Vadigepalli, PhD

Contact Dr. Vadigepalli

1020 Locust Street
314 Alumni Hall
Philadelphia, PA 19107

(215) 955-0576
(215) 503-2636 fax

Medical School

PhD, University of Delaware, Chemical Engineering - 2001
BTech, Indian Institute of Technology Madras, Chemical Engineering - 1996

University Appointment

Associate Professor, Department of Pathology, Anatomy & Cell Biology

Research and Clinical Interests

Work in Dr. Vadigepalli's lab is directed at understanding the regulatory network dynamics driving the cellular adaptive processes in mammalian pathophysiology. Though cross-disciplinary collaborative projects, we study signaling and gene regulatory networks in : central cardiorespiratory control circuits adversely adapted in hypertension, alcohol toxicity on liver repair and regeneration, and abnormal stem cell differentiation in the context of fetal alcohol spectrum disorders. We use computational modeling, systems engineering and bioinformatics approaches to complement high-throughout experimentation. Trainees in the lab have the opportunity to gain experience in the computational modeling and analysis including transcriptional profiling, genome-wide localization, and next generation sequencing approaches; and experimental methods for high-throughout validation of gene regulatory mechanisms.

Click here for Vadigepalli Laboratory

Publications

Most Recent Peer-Reviewed Publications

  1. Novel influences of IL-10 on CNS inflammation revealed by integrated analyses of cytokine networks and microglial morphology
  2. A data-driven modeling approach to identify disease-specific multi-organ networks driving physiological dysregulation
  3. Pattern analysis uncovers a chronic ethanol-induced disruption of the switchlike dynamics of C/EBP-β and C/EBP-α genome-wide binding during liver regeneration
  4. Single-cell transcriptional analysis reveals novel neuronal phenotypes and interaction networks involved in the central circadian clock
  5. Systemic leukotriene B4 receptor antagonism lowers arterial blood pressure and improves autonomic function in the spontaneously hypertensive rat
  6. Computational Modeling of Spatiotemporal Ca2+Signal Propagation Along Hepatocyte Cords
  7. Integrated live imaging and molecular profiling of embryoid bodies reveals a synchronized progression of early differentiation
  8. A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration
  9. A novel comparative pattern count analysis reveals a chronic ethanol-induced dynamic shift in immediate early NF-κB genome-wide promoter binding during liver regeneration
  10. Modeling cytokine regulatory network dynamics driving neuroinflammation in central nervous system disorders
  11. Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes
  12. Erratum: Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes (J Comput Neurosci, DOI 10.1007/s10827-015-0584-2)
  13. Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats
  14. HuR contributes to TRAIL resistance by restricting death receptor 4 expression in pancreatic cancer cells
  15. Systems analysis of non-parenchymal cell modulation of liver repair across multiple regeneration modes
  16. In vivo zonal variation and liver cell-type specific NF-κB localization after chronic adaptation to ethanol and following partial hepatectomy
  17. MicroRNA network changes in the brain stem underlie the development of hypertension
  18. Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology
  19. Intracellular Information Processing through Encoding and Decoding of Dynamic Signaling Features
  20. Identifying functional gene regulatory network phenotypes underlying single cell transcriptional variability