Philadelphia University + Thomas Jefferson University

Sperling, Michael R

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Michael R. Sperling, MD

Contact Dr. Sperling

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 955-1222
(215) 503-4358 fax

Research and Clinical Interests

Clinical epilepsy, EEG

The research program in the Jefferson Comprehensive Epilepsy Center is multifaceted, reflecting the interests of the ten faculty members in the center. We are investigating various aspects of epilepsy, including novel treatments, autonomic effects of seizures, electrophysiology of seizures, new approaches to neuroimaging, and developing improved methods of prognostication in epilepsy. Pharmacologic studies investigate the metabolic consequences of antiepileptic medication, with specific attention to serologic markers of vascular risk. Neuroimaging studies are exploring connections between different brain areas in epilepsy, cognitive organization, memory, and language function in epilepsy. Electrographic studies of seizures hope to improve methods for mapping seizure spread within the brain with the goal of defining abnormal circuitry in epilepsy. Autonomic studies investigate cardiac rhythm disturbances in epilepsy, with companion epidemiologic studies of mortality in epilepsy. Long-term outcome studies of epilepsy surgery explore the consequences of cortical resection for this condition in medical, cognitive, linguistic, and psychosocial domains.

The techniques used in our research are those used in clinical studies, including MRI, fMRI, EEG, metabolic and pharmacologic measures, and epidemiologic methods.


Most Recent Peer-Reviewed Publications

  1. Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation
  2. Closed-loop stimulation of temporal cortex rescues functional networks and improves memory
  3. An interview with Divyanshu Dubey, 2018 Epilepsia Prize winner for clinical research
  4. An interview with Kyle Thomson, 2018 Epilepsia Prize Winner for Basic Science Research
  5. Presurgical depression and anxiety are not associated with worse epilepsy surgery outcome five years postoperatively
  6. Epileptologist's view: Laser interstitial thermal ablation for treatment of temporal lobe epilepsy
  7. Disrupted dynamic network reconfiguration of the language system in temporal lobe epilepsy
  8. Common data elements for epilepsy mobile health systems
  9. Task activation and functional connectivity show concordant memory laterality in temporal lobe epilepsy
  10. Automated trajectory planning for laser interstitial thermal therapy in mesial temporal lobe epilepsy
  11. Evidence for verbal memory enhancement with electrical brain stimulation in the lateral temporal cortex
  12. Electrophysiological signatures of spatial boundaries in the human subiculum
  13. Increased neuronal synchrony prepares mesial temporal networks for seizures of neocortical origin
  14. Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine
  15. Long-term surveillance of SUDEP in drug-resistant epilepsy patients treated with VNS therapy
  16. A method for the topographical identification and quantification of high frequency oscillations in intracranial electroencephalography recordings
  17. Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively
  18. Electrical stimulation modulates high γ activity and human memory performance
  19. Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition
  20. Erratum to “Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study” (Epilepsy Res. (2017) 131 (70–75) (S0920121116302789) (10.1016/j.eplepsyres.2017.02.007))