Philadelphia University + Thomas Jefferson University

Sperling, Michael R

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Michael R. Sperling, MD

Contact Dr. Sperling

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 955-1222
(215) 503-4358 fax

Research and Clinical Interests

Clinical epilepsy, EEG

The research program in the Jefferson Comprehensive Epilepsy Center is multifaceted, reflecting the interests of the ten faculty members in the center. We are investigating various aspects of epilepsy, including novel treatments, autonomic effects of seizures, electrophysiology of seizures, new approaches to neuroimaging, and developing improved methods of prognostication in epilepsy. Pharmacologic studies investigate the metabolic consequences of antiepileptic medication, with specific attention to serologic markers of vascular risk. Neuroimaging studies are exploring connections between different brain areas in epilepsy, cognitive organization, memory, and language function in epilepsy. Electrographic studies of seizures hope to improve methods for mapping seizure spread within the brain with the goal of defining abnormal circuitry in epilepsy. Autonomic studies investigate cardiac rhythm disturbances in epilepsy, with companion epidemiologic studies of mortality in epilepsy. Long-term outcome studies of epilepsy surgery explore the consequences of cortical resection for this condition in medical, cognitive, linguistic, and psychosocial domains.

The techniques used in our research are those used in clinical studies, including MRI, fMRI, EEG, metabolic and pharmacologic measures, and epidemiologic methods.

Publications

Most Recent Peer-Reviewed Publications

  1. Erratum to “Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study” (Epilepsy Res. (2017) 131 (70–75) (S0920121116302789) (10.1016/j.eplepsyres.2017.02.007))
  2. Bimodal coupling of ripples and slower oscillations during sleep in patients with focal epilepsy
  3. Detection of generalized tonic–clonic seizures using surface electromyographic monitoring
  4. Atlas of Electroencephalography, 3rd Edition
  5. Similar patterns of neural activity predict memory function during encoding and retrieval
  6. Response to the numbering of seizure types
  7. Presurgical thalamic "hubness" predicts surgical outcome in temporal lobe epilepsy
  8. Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans
  9. Laser thermal ablation for treatment of drug-resistant epilepsy: Experiences from Philadelphia | Laser-Thermoablation zur Behandlung von pharmakoresistenten Epilepsien: Erfahrungen aus Philadelphia
  10. From “rest” to language task: Task activation selects and prunes from broader resting-state network
  11. Stimulation of the human medial temporal lobe between learning and recall selectively enhances forgetting
  12. Dissecting gamma frequency activity during human memory processing
  13. Contextually Mediated Spontaneous Retrieval Is Specific to the Hippocampus
  14. Randomized, double-blind, placebo-controlled phase 2 study of ganaxolone as add-on therapy in adults with uncontrolled partial-onset seizures
  15. Absolute spike frequency as a predictor of surgical outcome in temporal lobe epilepsy
  16. Instruction manual for the ILAE 2017 operational classification of seizure types
  17. Drug-resistant parietal lobe epilepsy: clinical manifestations and surgery outcome
  18. Postsurgical outcome in patients with olfactory auras and drug-resistant epilepsy
  19. Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study
  20. Interictal epileptiform discharges impair word recall in multiple brain areas