Philadelphia University + Thomas Jefferson University

Sperling, Michael R

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Michael R. Sperling, MD

Contact Dr. Sperling

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 955-1222
(215) 503-4358 fax

Research and Clinical Interests

Clinical epilepsy, EEG

The research program in the Jefferson Comprehensive Epilepsy Center is multifaceted, reflecting the interests of the ten faculty members in the center. We are investigating various aspects of epilepsy, including novel treatments, autonomic effects of seizures, electrophysiology of seizures, new approaches to neuroimaging, and developing improved methods of prognostication in epilepsy. Pharmacologic studies investigate the metabolic consequences of antiepileptic medication, with specific attention to serologic markers of vascular risk. Neuroimaging studies are exploring connections between different brain areas in epilepsy, cognitive organization, memory, and language function in epilepsy. Electrographic studies of seizures hope to improve methods for mapping seizure spread within the brain with the goal of defining abnormal circuitry in epilepsy. Autonomic studies investigate cardiac rhythm disturbances in epilepsy, with companion epidemiologic studies of mortality in epilepsy. Long-term outcome studies of epilepsy surgery explore the consequences of cortical resection for this condition in medical, cognitive, linguistic, and psychosocial domains.

The techniques used in our research are those used in clinical studies, including MRI, fMRI, EEG, metabolic and pharmacologic measures, and epidemiologic methods.


Most Recent Peer-Reviewed Publications

  1. Closed-loop stimulation of temporal cortex rescues functional networks and improves memory
  2. Task activation and functional connectivity show concordant memory laterality in temporal lobe epilepsy
  3. Increased neuronal synchrony prepares mesial temporal networks for seizures of neocortical origin
  4. Long-term surveillance of SUDEP in drug-resistant epilepsy patients treated with VNS therapy
  5. Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine
  6. A method for the topographical identification and quantification of high frequency oscillations in intracranial electroencephalography recordings
  7. Automated trajectory planning for laser interstitial thermal therapy in mesial temporal lobe epilepsy
  8. Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively
  9. Electrical stimulation modulates high γ activity and human memory performance
  10. Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition
  11. Erratum to “Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study” (Epilepsy Res. (2017) 131 (70–75) (S0920121116302789) (10.1016/j.eplepsyres.2017.02.007))
  12. Bimodal coupling of ripples and slower oscillations during sleep in patients with focal epilepsy
  13. Detection of generalized tonic–clonic seizures using surface electromyographic monitoring
  14. Atlas of Electroencephalography, 3rd Edition
  15. Similar patterns of neural activity predict memory function during encoding and retrieval
  16. An interview with Sarah Weckhuysen, 2017 Epilepsia Prize Winner for Clinical Research
  17. An interview with Tiwalade Sobayo, 2017 Epilepsia Prize Winner for Basic Science Research
  18. Response to the numbering of seizure types
  19. Presurgical thalamic "hubness" predicts surgical outcome in temporal lobe epilepsy
  20. Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans