Philadelphia University + Thomas Jefferson University

Sigal, Luis

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Luis Sigal, DVM, PhD

Contact Dr. Sigal

233 South 10th Street
Room 709 BLSB
Philadelphia, PA 19107

(215) 503-4534

Research and Clinical Interests

Antigen presentation in viral infections and mechanisms of natural and acquired resistance to ectromelia virus.


Most Recent Peer-Reviewed Publications

  1. DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death
  2. Activation of CD8 T Lymphocytes during Viral Infections
  3. The Pathogenesis and Immunobiology of Mousepox
  4. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment
  5. Protective CD8+T cell memory without help
  6. CD4+T cell help is dispensable for protective CD8+T cell memory against mousepox virus following vaccinia virus immunization
  7. Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection
  8. Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth
  9. Impact of distinct poxvirus infections on the specificities and functionalities of CD4+T cell responses
  10. MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve toll-like receptor 2
  11. Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection
  12. Immunology: Memory cells sound the alarm
  13. Memory CD8+T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection
  14. Getting in front and behind the enemy lines to counter virus infection
  15. Memory CD8<sup>+</sup> T cell protection
  16. Characterization of ectromelia virus deficient in EVM036, thehomolog of vaccinia virus F13l, and its application for rapid generation of recombinant viruses
  17. Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease
  18. Perforin-dependent CD4+T-cell cytotoxicity contributes to control a murine poxvirus infection
  19. Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver
  20. Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8 + T cell response