Philadelphia University + Thomas Jefferson University

Schwaber, James S.

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James S. Schwaber, PhD

Contact Dr. Schwaber

1020 Locust Street
Jefferson Alumni Hall, Suite 381
Philadelphia, PA 19107

(215) 503-7823

Medical School

PhD, University of Miami - 1973

University Appointment

Associate Professor
Director of Daniel Baugh Institute for Functional Genomics and Computational Biology; Department of Pathology, Anatomy & Cell Biology

Other Professional Appointments

Adjunct Professor Chemical Engineering, University of Delaware

Research and Clinical Interests

Dr. Schwaber uses systems biology approaches in mammalian brain to study adaptive neuronal processes. Specifically his interests involve mechanisms by which hypertension arises in homeostatic cardiorespiratory regulatory circuits, by which the symptoms of alcohol withdrawal are produced and by which phase shifting of light causes the brain's master clock to reorganize circadian behavior.


Most Recent Peer-Reviewed Publications

  1. Multiscale modeling in the clinic: diseases of the brain and nervous system
  2. A data-driven modeling approach to identify disease-specific multi-organ networks driving physiological dysregulation
  3. Single-cell transcriptional analysis reveals novel neuronal phenotypes and interaction networks involved in the central circadian clock
  4. Systemic leukotriene B4receptor antagonism lowers arterial blood pressure and improves autonomic function in the spontaneously hypertensive rat
  5. The role of the gut-brain axis in alcohol use disorders
  6. MicroRNA network changes in the brain stem underlie the development of hypertension
  7. Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology
  8. Identifying functional gene regulatory network phenotypes underlying single cell transcriptional variability
  9. Intracellular Information Processing through Encoding and Decoding of Dynamic Signaling Features
  10. Computational modeling of cytokine signaling in microglia
  11. What is it to be Conscious?
  12. Inputs drive cell phenotype variability
  13. Dynamic transcriptomics: Transcriptomic discovery of a biological multiple-input multiple-output heart control mechanism
  14. Coordinated Dynamic Gene Expression Changes in the Central Nucleus of the Amygdala During Alcohol Withdrawal
  15. Rapid Temporal Changes in the Expression of a Set of Neuromodulatory Genes During Alcohol Withdrawal in the Dorsal Vagal Complex: Molecular Evidence of Homeostatic Disturbance
  16. Integrative gene regulatory network analysis reveals light-induced regional gene expression phase shift programs in the mouse suprachiasmatic nucleus
  17. Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei
  18. The neuroscience-systems biology disconnect: Towards the NeuroPhysiome
  19. Adaptive transcriptional dynamics of A2 neurons and central cardiovascular control pathways
  20. Robust dynamic balance of AP-1 transcription factors in a neuronal gene regulatory network