Philadelphia University + Thomas Jefferson University

Schneider, Jay S.

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Jay S. Schneider, PhD

Contact Dr. Schneider

1020 Locust Street
Jefferson Alumni Hall, Suite 521
Philadelphia, PA 19107

(215) 503-0370

Medical School

PhD, SUNY at Stony Brook - 1981

University Appointment

Professor, Department of Pathology, Anatomy & Cell Biology

Research and Clinical Interests

Basic, clinical and translational research on cognitive and motor aspects of Parkinson's disease with focuses on both symptomatic and neuroprotective treatment strategies; basic and clinical research on developmental neurotoxicology with an emphasis on lead-induced damage to the brain.


Most Recent Peer-Reviewed Publications

  1. Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores
  2. Developmental lead and/or prenatal stress exposures followed by different types of behavioral experience result in the divergence of brain epigenetic profiles in a sex, brain region, and time-dependent manner: Implications for neurotoxicology
  3. Strain specific effects of low level lead exposure on associative learning and memory in rats
  4. Sex- and brain region- specific effects of prenatal stress and lead exposure on permissive and repressive post-translational histone modifications from embryonic development through adulthood
  5. Caffeine, creatine, GRIN2A and Parkinson's disease progression
  6. Effects of low level lead exposure on associative learning and memory in the rat: Influences of sex and developmental timing of exposure
  7. Epigenetic mechanisms of adverse neurodevelopment in response to lead exposure and prenatal stress and the combination: The road ahead
  8. Rearing environment, sex and developmental lead exposure modify gene expression in the hippocampus of behaviorally naïve animals
  9. Sex and rearing condition modify the effects of perinatal lead exposure on learning and memory
  10. Differential effect of postnatal lead exposure on gene expression in the hippocampus and frontal cortex
  11. Broad neuroprotective profile of nicotinamide in different mouse models of MPTP-induced parkinsonism
  12. Striatal preprotachykinin gene expression reflects parkinsonian signs