Philadelphia University + Thomas Jefferson University

Ronner, Peter

< Back

Profile

Peter Ronner, PhD

Peter Ronner, PhD

Contact Dr. Ronner

233 South Tenth Street
250 BLSB
Philadelphia, PA 19107

(215) 503-5190
(215) 923-9162 fax

Research & Clinical Interests

I am interested in the mechanisms which control the release of insulin and glucagon from the pancreas.

Most of my current work is focused on glucagon release. We found that non-B islet cells (most likely glucagon-secreting A-cells) contain ATP-sensitive K-channels (KATP) that are pharmacologically and electrophysiologically indistinguishable from those in insulin-secreting B-cells. I am interested in defining the role of KATP in the regulation of both insulin and glucagon release.

In our studies of normal and tumoral pancreatic endocrine cells we use electrophysiology, flow-cytometric cell-sorting, immunohistochemistry, radioimmunoassays, and sensitive luminometric microhistochemical assays, which we developed recently.

Previously, I have studied the Ca,Mg-ATPase of human erythrocyte membranes, and hormone release from the in vitro micro-perfused endocrine pancreas (weight ~5 mg) of channel catfish (Ictalurus nebulosus).

Publications

Most Recent Peer-Reviewed Publications

  1. Effects of glucose and amino acids on free ADP in βHC9 insulin-secreting cells
  2. Luminometric assays of ATP, phosphocreatine, and creatine for estimation of free ADP and free AMP
  3. Perfusion of pancreatic endocrine tissue of teleost fish
  4. Sulfonylurea-binding sites and ATP-sensitive K+ channels in α-TC glucagonoma and β-TC insulinoma cells
  5. Effect of the hypoglycaemic drug (−)‐AZ‐DF‐265 on ATP‐sensitive potassium channels in rat pancreatic β‐cells
  6. The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet β-cells in the isolated perfused rat pancreas
  7. Inhibition of ATP-sensitive K+ channels in pancreatic β-cells by nonsulfonylurea drug linogliride
  8. 2-Deoxyglucose stimulates the release of insulin and somatostatin from the perfused catfish pancreas
  9. Effect of linogliride on hormone release from perfused rat pancreas: Fuel dependence and desensitization by tolbutamide
  10. Secretagogues for pancreatic hormone release in the channel catfish (Ictalurus punctatus)
  11. Transmembrane Ion Distribution and Insulin Secretion
  12. Difference in dose-response curves for glucose-induced insulin and somatostatin release in rat pancreas
  13. Isolation and structures of glucagon and glucagon-like peptide from catfish pancreas
  14. Difference in glucose dependency of insulin and somatostatin release.
  15. Difference in glucose dependency of insulin and somatostatin release
  16. Isolated perfused Brockmann body as a model for studying pancreatic endocrine secretion
  17. Isolated perfused Brockmann body as a model for studying pancreatic endocrine secretion.
  18. Effects of calmodulin on the (Ca2+ + Mg2+)ATPase partially purified from erythrocyte membranes
  19. Partial purification and reconstitution of the (Ca2+ + Mg2+)-ATPase of erythrocyte membranes
  20. A lipid requirement for the (Ca2+ + Mg2+)-activated ATPase of erythrocyte membranes