Philadelphia University + Thomas Jefferson University

Penn, Raymond

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Raymond B. Penn, PhD

Raymond B. Penn, PhD

Contact Dr. Penn

Center for Translational Medicine
1025 Walnut Street, Suite 317
Philadelphia, PA 19107

(215) 955-9982
(215) 503-5731 fax

Research & Clinical Interests

Airway biology; GPCR biology; Asthma pharmacology; Renal transporter biology; Cancer biology; Asthma, COPD, obstructive and fibrotic lung diseases; Chronic metabolic acidosis

The major focus of my research is to identify cellular and molecular mechanisms by which G protein-coupled receptors (GPCRs) mediate important functions in airway cells. GPCR signaling regulates contractile function, synthesis and release of autocrine factors, and cell growth/survival in various airway cells, including airway smooth muscle (ASM), airway epithelium, lung fibroblasts, and T lymphocytes. Aberrant GPCR signaling or exaggerated presentation of GPCR stimuli can promote ASM hypercontractility, airway remodeling, and ASM hyperplasia/hypertrophy, all of which contribute to the pathogenesis of asthma and COPD. Moreover, GPCRs appear to mediate important mitogenic and survival signaling pathways in cells comprising the tumor microenvironment- including epithelia, fibroblasts, stem cells, and inflammatory cells- rendering them potentially important therapeutic targets in the treatment of cancer. Finally, many GPCR genes possess mutations that alter their expression or function; we are particularly interested in characterizing such altered function and its contribution to disease state or disease therapy.

Publications

Most Recent Peer-Reviewed Publications

  1. Pepducins as a potential treatment strategy for asthma and COPD
  2. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines
  3. Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone
  4. 12facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner
  5. An official American thoracic society research statement: Current challenges facing research and therapeutic advances in airway remodeling
  6. Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones
  7. Phosphodiesterase 4 inhibitors attenuate the asthma phenotype produced by β2-adrenoceptor agonists in phenylethanolamine N-methyltransferase-knockout mice
  8. β2Agonists
  9. Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a
  10. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
  11. Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function
  12. Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
  13. A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis
  14. Calcilytics for asthma relief
  15. β-agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent
  16. Far from "disappointing"
  17. Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway
  18. GPCRs and arrestins in Airways: Implications for asthma
  19. Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle
  20. cAMP regulation of airway smooth muscle function