Philadelphia University + Thomas Jefferson University

Mahoney, My

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My G. Mahoney, PhD

Contact Dr. Mahoney

233 South 10th Street
Room 428
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Research and Clinical Interests

Roles of desmosomal proteins in regulating epithelial cell adhesion, growth and survival; deregulation of desmosomal proteins in autoimmune, infectious, and inherited diseases associated with fragility and abnormality in diverse tissues such as the skin, hair and heart; mechanisms by which desmosomal cadherins can modulate mitogenic signaling pathways; genetically manipulated animal models to study human diseases.

Publications

Most Recent Peer-Reviewed Publications

  1. Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion
  2. Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris
  3. Inhibition of apoptosis signal-regulating kinase 1 alters the wound epidermis and enhances auricular cartilage regeneration
  4. Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes
  5. Palmitoylation of desmoglein 2 is a regulator of assembly dynamics and protein turnover
  6. C-Src/Cav1-dependent activation of the EGFR by Dsg2
  7. Expression of transforming growth factor-β after different non-invasive facial rejuvenation modalities
  8. Cell cycle- and cancer-associated gene networks activated by Dsg2: Evidence of cystatin a deregulation and a potential role in cell-cell adhesion
  9. Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis
  10. Lipid rafts and detergent-resistant membranes in epithelial keratinocytes
  11. Lipid rafts and detergent-resistant membranes in epithelial keratinocytes
  12. Reduced fibulin-2 contributes to loss of basement membrane integrity and skin blistering in mice lacking integrin α3β1 in the epidermis
  13. Palmitoylation of plakophilin is required for desmosome assembly
  14. Expression of p53 protein after nonablative rejuvenation: The other side of the coin
  15. Efficacy of mesotherapy in facial rejuvenation: A histological and immunohistochemical evaluation
  16. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca 2+/Mn 2+ ATPase SPCA1 in cultured keratinocytes
  17. Multiple minimally invasive Erbium: Yttrium Aluminum Garnet laser mini-peels for skin rejuvenation: An objective assessment
  18. A role for caveolin-1 in desmoglein binding and desmosome dynamics
  19. Noncanonical Hedgehog Signaling
  20. Intense pulsed light photorejuvenation: A histological and immunohistochemical evaluation