Philadelphia University + Thomas Jefferson University

Mahoney, My

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My G. Mahoney, PhD

Contact Dr. Mahoney

233 South 10th Street
Room 428
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Research and Clinical Interests

Roles of desmosomal proteins in regulating epithelial cell adhesion, growth and survival; deregulation of desmosomal proteins in autoimmune, infectious, and inherited diseases associated with fragility and abnormality in diverse tissues such as the skin, hair and heart; mechanisms by which desmosomal cadherins can modulate mitogenic signaling pathways; genetically manipulated animal models to study human diseases.

Publications

Most Recent Peer-Reviewed Publications

  1. Inhibition of apoptosis signal-regulating kinase 1 alters the wound epidermis and enhances auricular cartilage regeneration
  2. Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes
  3. Palmitoylation of desmoglein 2 is a regulator of assembly dynamics and protein turnover
  4. C-Src/Cav1-dependent activation of the EGFR by Dsg2
  5. Expression of transforming growth factor-β after different non-invasive facial rejuvenation modalities
  6. Cell cycle- and cancer-associated gene networks activated by Dsg2: Evidence of cystatin a deregulation and a potential role in cell-cell adhesion
  7. Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis
  8. Lipid rafts and detergent-resistant membranes in epithelial keratinocytes
  9. Reduced fibulin-2 contributes to loss of basement membrane integrity and skin blistering in mice lacking integrin α3β1 in the epidermis
  10. Palmitoylation of plakophilin is required for desmosome assembly
  11. Expression of p53 protein after nonablative rejuvenation: The other side of the coin
  12. Efficacy of mesotherapy in facial rejuvenation: A histological and immunohistochemical evaluation
  13. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca 2+/Mn 2+ ATPase SPCA1 in cultured keratinocytes
  14. Multiple minimally invasive Erbium: Yttrium Aluminum Garnet laser mini-peels for skin rejuvenation: An objective assessment
  15. A role for caveolin-1 in desmoglein binding and desmosome dynamics
  16. Noncanonical Hedgehog Signaling
  17. Effects of the Nd:YAG 1320-nm laser on skin rejuvenation: Clinical and histological correlations
  18. Radiofrequency facial rejuvenation: Evidence-based effect
  19. Electro-optical synergy technique a new and effective nonablative approach to skin aging
  20. Compound heterozygous desmoplakin mutations result in a phenotype with a combination of myocardial, skin, hair, and enamel abnormalities