Philadelphia University + Thomas Jefferson University

Londin, Eric

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Eric Londin, PhD

Eric Londin, PhD

Contact Dr. Londin

1020 Locust Street
JAH - M81
Philadelphia, PA 19107

(215) 503-0454
(215) 503-0466 fax

Research & Clinical Interests

Dr. Londin is interested in the characterization of and role of microRNAs (miRNA) in the human diseases. MiRNAs are short ~22 nt RNAs that are typically derived from endogenous hairpin transcripts.  miRNAs interact with targeted RNAs in a sequence dependent manner to post-transcriptionally regulate gene expression either by translation inhibition, exonuclease-mediated mRNA degradation, or disruption of cap-tail interactions. We are working to address several key questions regarding miRNAs: (i) how many miRNAs are present in the genome, (ii) what is the composition of the miRNAs (iii) what genes do the miRNAs target, and (iv) what is the role of miRNAs in human disease? To address these questions, we are using a combination of computational and molecular biology techniques.


Most Recent Peer-Reviewed Publications

  1. Profiles of miRNA Isoforms and tRNA Fragments in Prostate Cancer
  2. Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy
  3. Whole exome sequencing identifies a germline MET mutation in two siblings with hereditary wild-type RET medullary thyroid cancer
  4. MINTbase v2.0: A comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all the Cancer Genome Atlas projects
  5. Posttranscriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors
  6. Posttranscriptional upregulation of IDH1 by HuR establishes a powerful survival phenotype in pancreatic cancer cells
  7. Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
  8. Threshold-seq: A tool for determining the threshold in short RNA-seq datasets
  9. CRISPR knockout of the HuR gene causes a xenograft lethal phenotype
  10. Assessment of isomiR discrimination using commercial qPCR methods
  11. Post-transcriptional regulation of BRCA2 through interactions with miR-19a and miR-19b
  12. GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR
  13. Next generation sequencing in cancer: opportunities and challenges for precision cancer medicine
  14. High concentration capture probes enhance massively parallel sequencing assays
  15. The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells
  16. Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types
  17. Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity
  18. What is translational bioinformatics?
  19. Reply to Backes and Keller: Identification of novel tissue-specific and primate-specific human microRNAs
  20. Clinical exome performance for reporting secondary genetic findings