Philadelphia University + Thomas Jefferson University

Londin, Eric

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Eric Londin, PhD

Eric Londin, PhD

Contact Dr. Londin

1020 Locust Street
JAH - M81
Philadelphia, PA 19107

(215) 503-0454
(215) 503-0466 fax

Research & Clinical Interests

Dr. Londin is interested in the characterization of and role of microRNAs (miRNA) in the human diseases. MiRNAs are short ~22 nt RNAs that are typically derived from endogenous hairpin transcripts.  miRNAs interact with targeted RNAs in a sequence dependent manner to post-transcriptionally regulate gene expression either by translation inhibition, exonuclease-mediated mRNA degradation, or disruption of cap-tail interactions. We are working to address several key questions regarding miRNAs: (i) how many miRNAs are present in the genome, (ii) what is the composition of the miRNAs (iii) what genes do the miRNAs target, and (iv) what is the role of miRNAs in human disease? To address these questions, we are using a combination of computational and molecular biology techniques.

Publications

Most Recent Peer-Reviewed Publications

  1. Posttranscriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors
  2. Posttranscriptional upregulation of IDH1 by HuR establishes a powerful survival phenotype in pancreatic cancer cells
  3. Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
  4. Threshold-seq: A tool for determining the threshold in short RNA-seq datasets
  5. CRISPR knockout of the HuR gene causes a xenograft lethal phenotype
  6. Post-transcriptional regulation of BRCA2 through interactions with miR-19a and miR-19b
  7. GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR
  8. Next generation sequencing in cancer: opportunities and challenges for precision cancer medicine
  9. High concentration capture probes enhance massively parallel sequencing assays
  10. The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells
  11. Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types
  12. Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity
  13. What is translational bioinformatics?
  14. Reply to Backes and Keller: Identification of novel tissue-specific and primate-specific human microRNAs
  15. Clinical exome performance for reporting secondary genetic findings
  16. Performance of exome sequencing for pharmacogenomics
  17. Argonaute CLIP-Seq reveals miRNA targetome diversity across tissue types
  18. HuR posttranscriptionally regulates WEE1: Implications for the DNA damage response in pancreatic cancer cells
  19. The human platelet: Strong transcriptome correlations among individuals associate weakly with the platelet proteome
  20. IsomiR expression profiles in human lymphoblastoid cell lines exhibit population and gender dependencies