Philadelphia University + Thomas Jefferson University

Languino, Lucia

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Lucia R. Languino, PhD

Contact Dr. Languino

233 South 10th Street
Suite 506
Philadelphia, PA 19107

(215) 503-3442

Research and Clinical Interests

Studies of the signaling pathways that contribute to prostate cancer progression and metastasis.

Dr. Languino investigates the role of cell adhesion receptors in phenotypic changes of prostate cancer cells. A strong research focus is being devoted to the study of the cross-talk between cell adhesion molecules, extracellular matrix proteins and growth factor receptors in vitro and in vivo systems and how this cross-talk affects intracellular signal transduction, cell survival, cell migration and cell division. Dr. Languino's research interests also focus on the cellular and molecular characterization of the metastatic process of prostate cancer with particular emphasis on the signals directing distant localization of prostate cancer cells

Publications

Most Recent Peer-Reviewed Publications

  1. Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors
  2. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer
  3. A neuronal network of mitochondrial dynamics regulates metastasis
  4. Transgenic expression of the mitochondrial chaperone TNFR-associated protein 1 (TRAP1) accelerates prostate cancer development
  5. Exosome-mediated transfer of αvβ3 integrin from tumorigenic to nontumorigenic cells promotes a migratory phenotype
  6. αvβ6 integrin promotes castrate-resistant prostate cancer through JNK1-mediated activation of androgen receptor
  7. β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation
  8. Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism
  9. Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1
  10. Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer
  11. PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
  12. Deregulation of MIR-34b/Sox2 predicts prostate cancer progression
  13. Erratum: Landscape of the mitochondrial Hsp90 metabolome in tumours (Nature Communications (2013) 4 (2139) DOI:10.1038/ncomms3139)
  14. αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression
  15. The α<inf>v</inf>β<inf>6</inf> integrin is transferred intercellularly via exosomes
  16. Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion
  17. Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts
  18. Adaptive mitochondrial reprogramming and resistance to PI3K therapy
  19. Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks
  20. Integrin avb6 Promotes an osteolytic program in cancer cells by upregulating MMP2