Philadelphia University + Thomas Jefferson University

Iwamoto, Masahiro

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Masahiro Iwamoto, DDS, PhD

Contact Dr. Iwamoto

1015 Walnut Street
Curtis Building, Room 501
Philadelphia, PA 19107

(215) 955-4076
(215) 955-9159 fax

Medical School

DDS, Tokushima University, School of Dental Medicine - 1984
PhD, Osaka University, Graduate School of Dentistry - 1988

Expertise and Research Interests

During embryogenesis, chondrocytes at the epiphyseal tip of long bone models give rise to articular tissue and persist through life, whereas chondrocytes in the shaft undergo hypertrophy, mineralization and apoptosis and are replaced by bone cells. It is not understood how chondrocytes undertake these alternative pathways and fates. We have been reported that C-1-1, a novel isoform of chick ets-related gene (ERG) is preferentially expressed in articular cartilage and its expression is down-regulated during maturation of chondrocytes. Over-expression of C-1-1 not only inhibits maturation of chondrocytes but also converts type X collagen positive trangient chondrocytes to tenascin-C positive permanent articular chondrocytes like cells. In developing mouse skeleton, ERG is highly expressed in future joint region and surface zone of articular cartilage. Those findings suggest that ERG plays an important role in permanent articular cartilage formation. We are studying mechanism of action, regulation of expression, interaction and interplay with other signaling factors, and the effect of down-regulation of ERG in chondrocytes.

Languages

English
Japanese

Publications

Most Recent Peer-Reviewed Publications

  1. Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent
  2. Reactivation of hepatitis B virus in rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs
  3. The role of sonic hedgehog signaling in osteoclastogenesis and jaw bone destruction
  4. Novel hedgehog agonists promote osteoblast differentiation in mesenchymal stem cells
  5. Selective Retinoic Acid Receptor γ Agonists Promote Repair of Injured Skeletal Muscle in Mouse
  6. Resident mesenchymal progenitors of articular cartilage
  7. The pathophysiology of heterotopic ossification: Current treatment considerations in dentistry
  8. Distribution of slow-cycling cells in epiphyseal cartilage and requirement of β-catenin signaling for their maintenance in growth plate
  9. Drug free REmission/low disease activity after cessation of tocilizumab (Actemra) Monotherapy (DREAM) study
  10. Retreatment efficacy and safety of tocilizumab in patients with rheumatoid arthritis in recurrence (RESTORE) study
  11. Sonic Hedgehog Regulates Osteoblast Function by Focal Adhesion Kinase Signaling in the Process of Fracture Healing
  12. Toward regeneration of articular cartilage
  13. Glucocorticoid-induced normotensive scleroderma renal crisis: A report on two cases and a review of the literature in Japan
  14. Posterior ischemic optic neuropathy in a patient with granulomatosis with polyangiitis (Wegener's)
  15. Fluorodeoxyglucose positron emission tomography/computed tomography for diagnostic imaging in relapsing polychondritis with atypical manifestations
  16. Loss of β-catenin induces multifocal periosteal chondroma-like masses in mice
  17. Foot ulcers caused by rheumatoid vasculitis in a patient with rheumatoid arthritis undergoing etanercept treatment
  18. Low level of seroconversion after a novel influenza A/H1N1/2009 vaccination in Japanese patients with rheumatoid arthritis in the 2009 season
  19. Erratum: Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists (Nat. Med. (2012) 17 (454-460))
  20. Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms