Philadelphia University + Thomas Jefferson University

Hoek, Jan B.

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Jan B. Hoek, PhD

Contact Dr. Hoek

1020 Locust Street
527 Alumni Hall
Philadelphia, PA 19107

(215) 503-5016
(215) 923-2218 fax

Medical School

PhD, University of Amsterdam - 1972

University Appointment

Professor, Department of Pathology, Anatomy & Cell Biology
Vice Chair for Research, Department of Pathology, Anatomy & Cell Biology

Research and Clinical Interests

Systems biology of intracellular signal transduction networks; deregulation of cytokine and growth factor signaling in the liver associated with chronic alcohol consumption; early signaling responses during liver regeneration; bioenergetics and mitochondrial metabolism and its role in intracellular signaling and apoptosis.

Research in my laboratory is focused on the analysis of integrated signaling responses in liver and other tissues and on the adaptive or maladaptive modification of these responses by acute and chronic ethanol exposure. The following project are currently ongoing:
Analysis of growth factor signaling networks and related gene expression profiles in liver, using a combination of computational modeling and experimental studies;
Signaling events associated with the onset and progression of liver regeneration, with emphasis on the control of energy metabolism, purinergic signaling and AMP-activated protein kinase;
Mechanisms of ethanol-associated disturbance of cellular Ca2+ homeostasis and Ca2+ signaling and its role in adaptation and stress-responses in the liver;
Mechanisms of ethanol-induced susceptibility to apoptotic signals in the liver.

Publications

Most Recent Peer-Reviewed Publications

  1. Alcohol-Mediated Missplicing of Mcl-1 Pre-mRNA is Involved in Neurotoxicity
  2. Biochemical effects of exercise on a fasciocutaneous flap in a rat model
  3. Chronic alcohol feeding potentiates hormone-induced calcium signalling in hepatocytes
  4. Mitochondrial Ca2+and regulation of the permeability transition pore
  5. Computational Modeling of Spatiotemporal Ca2+Signal Propagation Along Hepatocyte Cords
  6. Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity
  7. MICU1 regulation of mitochondrial Ca 2+ uptake dictates survival and tissue regeneration
  8. Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats
  9. Amygdalar neuronal plasticity and the interactions of alcohol, sex, and stress
  10. In vivo zonal variation and liver cell-type specific NF-κB localization after chronic adaptation to ethanol and following partial hepatectomy
  11. Multistrip western blotting: A tool for comparative quantitative analysis of multiple proteins
  12. Computational modeling analysis of mitochondrial superoxide production under varying substrate conditions and upon inhibition of different segments of the electron transport chain
  13. Silence on the relevant literature and errors in implementation
  14. Alcohol and breast cancer: Reconciling epidemiological and molecular data
  15. Multistrip western blotting: A tool for comparative quantitative analysis of multiple proteins
  16. Preface
  17. A novel, dynamic pattern-based analysis of NF-κB binding during the priming phase of liver regeneration reveals switch-like functional regulation of target genes
  18. Adiponectin fine-tuning of liver regeneration dynamics revealed through cellular network modelling
  19. Pharmacological ceramide reduction alleviates alcohol-induced steatosis and hepatomegaly in adiponectin knockout mice
  20. Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin