Philadelphia University + Thomas Jefferson University

Hardy, Richard

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Richard R. Hardy, PhD

Contact Dr. Hardy

333 Cottman Avenue
Fox Chase Cancer Center
Philadelphia, PA 19111

(215) 728-2469
(215) 728-2412 fax

Research and Clinical Interests

Developmental immunology of B cells, including their generation from stem cells in fetal liver and bone marrow; regulation of B-cell development by pre-BCR and BCR signaling; development of B-cell subsets, including B-1 B cells, with relevance to autoimmunity and leukemia. Most of this work uses the mouse as a model system, but recent studies include analysis of B cell receptors in chronic lymphocytic leukemia patient cells and a genetic screen in the zebrafish.

Publications

Most Recent Peer-Reviewed Publications

  1. Zebrafish b cell development without a pre-b cell stage, revealed by cd79 fluorescence reporter transgenes
  2. NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome
  3. Loss of a chromosomal region with synteny to human 13q14 occurs in mouse chronic lymphocytic leukemia that originates from early-generated B-1 B cells
  4. Expression profiling of constitutive mast cells reveals a unique identity within the immune system
  5. Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression
  6. A developmental switch between fetal and adult B lymphopoiesis
  7. B cells generated by B-1 development can progress to chronic lymphocytic leukemia
  8. Perspectives on fetal derived CD5+B1 B cells
  9. Mutagenesis screen identifies agtpbp1 and eps15L1 as essential for T lymphocyte development in zebrafish
  10. Selection of natural autoreactive B cells
  11. Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a
  12. Natural anti-intestinal goblet cell autoantibody production from marginal zone B cells
  13. Relationships among B Cell Populations Revealed by Global Gene Analysis
  14. Gene expression during the generation and activation of mouse neutrophils: Implication of novel functional and regulatory pathways
  15. Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains
  16. Leonard Herzenberg (1931-2013): the life of FACS.
  17. The transcriptional landscape of αβ T cell differentiation
  18. Identification of transcriptional regulators in the mouse immune system
  19. Transcriptional insights into the CD8 + T cell response to infection and memory T cell formation
  20. A role for IRF4 in the development of CLL