Philadelphia University + Thomas Jefferson University

Hardy, Richard

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Richard R. Hardy, PhD

Contact Dr. Hardy

333 Cottman Avenue
Fox Chase Cancer Center
Philadelphia, PA 19111

(215) 728-2469
(215) 728-2412 fax

Research and Clinical Interests

Developmental immunology of B cells, including their generation from stem cells in fetal liver and bone marrow; regulation of B-cell development by pre-BCR and BCR signaling; development of B-cell subsets, including B-1 B cells, with relevance to autoimmunity and leukemia. Most of this work uses the mouse as a model system, but recent studies include analysis of B cell receptors in chronic lymphocytic leukemia patient cells and a genetic screen in the zebrafish.


Most Recent Peer-Reviewed Publications

  1. Zebrafish b cell development without a pre-b cell stage, revealed by cd79 fluorescence reporter transgenes
  2. NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome
  3. Loss of a chromosomal region with synteny to human 13q14 occurs in mouse chronic lymphocytic leukemia that originates from early-generated B-1 B cells
  4. Expression profiling of constitutive mast cells reveals a unique identity within the immune system
  5. Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression
  6. A developmental switch between fetal and adult B lymphopoiesis
  7. B cells generated by B-1 development can progress to chronic lymphocytic leukemia
  8. Perspectives on fetal derived CD5+B1 B cells
  9. Mutagenesis screen identifies agtpbp1 and eps15L1 as essential for T lymphocyte development in zebrafish
  10. Selection of natural autoreactive B cells
  11. Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a
  12. Natural anti-intestinal goblet cell autoantibody production from marginal zone B cells
  13. Relationships among B Cell Populations Revealed by Global Gene Analysis
  14. Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains
  15. Gene expression during the generation and activation of mouse neutrophils: Implication of novel functional and regulatory pathways
  16. Leonard Herzenberg (1931-2013): the life of FACS.
  17. Identification of transcriptional regulators in the mouse immune system
  18. The transcriptional landscape of αβ T cell differentiation
  19. Transcriptional insights into the CD8 + T cell response to infection and memory T cell formation
  20. A role for IRF4 in the development of CLL