Philadelphia University + Thomas Jefferson University

Hajnoczky, Gyorgy

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Gyorgy Hajnoczky, MD, PhD

Gyorgy Hajnoczky, MD, PhD

Contact Dr. Hajnoczky

1020 Locust Street
527 Alumni Hall
Philadelphia, PA 19107

(215) 503-1427

Medical School

MD, Semmelweis University, Budapest - 1987
PhD, Semmelweis University, Budapest - 1987
National Academy of Sciences, Hungary - 1995

University Appointment

Raphael Rubin, MD Professor, Department of Pathology, Anatomy & Cell Biology

Research and Clinical Interests

Intracellular calcium signaling; inositol trisphosphate-linked hormones; organization of calcium mobilization from endoplasmic/sarcoplasmic reticulum; mitochondrial calcium signaling; calcium-dependent control over life and death of cells; fluorometric, fluorescence microscope imaging and electrophysiological approaches.

Signaling, calcium, ER, mitochondria, metabolism, apoptosis, imaging

Publications

Most Recent Peer-Reviewed Publications

  1. Recessive mutations in MSTO1 cause mitochondrial dynamics impairment, leading to myopathy and ataxia
  2. MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans
  3. Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling
  4. Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU
  5. Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity
  6. Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges
  7. Mitochondrial Nanotunnels
  8. Natural and induced mitochondrial phosphate carrier loss: Differential dependence of mitochondrial metabolism and dynamics and cell survival on the extent of depletion
  9. VDAC2-specific cellular functions and the underlying structure
  10. Subcellular ROS imaging methods: Relevance for the study of calcium signaling
  11. Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface
  12. MICU1 regulation of mitochondrial Ca 2+ uptake dictates survival and tissue regeneration
  13. Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis
  14. The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease
  15. Trans-mitochondrial coordination of cristae at regulated membrane junctions
  16. Mitochondrial ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity
  17. Erratum: MCUR1 is an essential component of mitochondrial Ca 2+ uptake that regulates cellular metabolism (Nat. Cell Biol. 14, 2012 (1336-1343))
  18. Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015
  19. Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease
  20. Distribution and Apoptotic Function of Outer Membrane Proteins Depend on Mitochondrial Fusion