Philadelphia University + Thomas Jefferson University

Fortini, Mark

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Mark Fortini, PhD

Contact Dr. Fortini

233 South 10th Street
830 BLSB
Philadelphia, PA 19107

(215) 503-7322

Expertise & Research Interests

Signaling mechanisms in neurogenesis and neurodegeneration; cell biology of Notch receptor trafficking and proteolysis; developmental genetics and human disease modeling in Drosophila.


Most Recent Peer-Reviewed Publications

  1. Transcriptomic Analysis of Drosophila Mushroom Body Neurons Lacking Amyloid-β Precursor-Like Protein Activity
  2. Disruption of Drosophila melanogaster Lipid Metabolism Genes Causes Tissue Overgrowth Associated with Altered Developmental Signaling
  3. Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup
  4. Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila
  5. Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila
  6. Introduction-Notch in development and disease
  7. Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects
  8. Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function
  9. Erratum to Retraction Notice to: The Big Brain Aquaporin Is Required for Endosome Maturation and Notch Receptor Trafficking [Cell, 133, (2008), 852-863]
  10. In Vivo reconstitution of γ-secretase in Drosophila results in substrate specificity
  11. Pharmacological analysis of Drosophila melanogaster γ-secretase with respect to differential proteolysis of notch and APP
  12. Endocytic regulation of Notch signaling
  13. Generation and characterization of monoclonal antibodies specific to Drosophila presenilin
  14. Notch Signaling: The Core Pathway and Its Posttranslational Regulation
  15. Inheritance of susceptibility to induction of nephroblastomas in the Noble rat
  16. The Big Brain Aquaporin Is Required for Endosome Maturation and Notch Receptor Trafficking
  17. Endosomal entry regulates Notch receptor activation in Drosophila melanogaster
  18. A role for presenilin in post-stress regulation: Effects of presenilin mutations on Ca2+ currents in Drosophila
  19. Anticipating trouble from gene transcription
  20. γ-Cleavage-Independent Functions of Presenilin, Nicastrin, and Aph-1 Regulate Cell-Junction Organization and Prevent Tau Toxicity In Vivo (DOI:10.1016/j.neuron.2006.03.038)