Philadelphia University + Thomas Jefferson University

Flomenberg, Phyllis

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Phyllis Flomenberg, MD

Contact Dr. Flomenberg

1015 Walnut Street
Room 812
Philadelphia, PA 19107

(215) 503-2170
(215) 923-1956 fax

Research and Clinical Interests

My focus of my research lab is on the analysis of human cellular immune responses to both viral pathogens and tumors and potential immunotherapy applications.

I have had a longstanding interest in adenovirus infections in patients with hematologic malignancies who undergo stem cell transplant recipients. I have an RO1 grant to characterize human T cell responses to adenoviruses in stem cell transplant recipients who develop adenovirus infections in order to develop immunotherapy strategies to help control invasive infections post-transplant, in collaboration with the Bone Marrow Transplant Program. Additionally, in collaboration with the Dept. of Neurosurgery, I have identified tumor-specific T cell responses in newly diagnosed patients with glioblastoma multiforme, suggesting that glioblastomas are immunogenic and may be amenable to immunotherapy.

Publications

Most Recent Peer-Reviewed Publications

  1. Disseminated Nocardia cyriacigeorgia causing pancreatitis in a haploidentical stem cell transplant recipient
  2. A two-step approach to myeloablative haploidentical transplantation: Low nonrelapse mortality and high survival confirmed in patients with earlier stage disease
  3. Disseminated adenovirus disease in heart transplant recipient presenting with conjunctivitis
  4. Adenoviruses
  5. Adenovirus infections
  6. Investigation of a Clostridium difficile cluster by multilocus sequence typing in a bone marrow transplant unit
  7. Clostridium difficile colonization and disease in patients undergoing hematopoietic stem cell transplantation
  8. A2-step approach to myeloablative haploidentical stem cell transplantation: A phase 1/2 trial performed with optimized T-cell dosing
  9. Risk factors for surgical site infections following spinal fusion procedures: A case-control study
  10. Comparison of human memory CD8 T cell responses to adenoviral early and late proteins in peripheral blood and lymphoid tissue
  11. Impact of a standardized protocol and antibiotic-impregnated catheteis on ventriculostomy infection rates in cerebrovascular patients
  12. Characterization of a single-cycle rabies virus-based vaccine vector
  13. Adenovirus infections
  14. Antiviral Responses following L-Leucyl-L-Leucine Methyl Esther (LLME)-Treated Lymphocyte Infusions: Graft-versus-Infection without Graft-versus-Host Disease
  15. Adenovirus DNA polymerase is recognized by human CD8+ T cells
  16. Emergence of Staphylococcal cassette chromosome mec type IV methicillin-resistant Staphylococcus aureus as a cause of ventilator-associated pneumonia
  17. Stem cell transplant recipient with multiple skin lesions
  18. Treatment of Adenovirus Disease in Stem Cell Transplant Recipients with Cidofovir
  19. Human T-cell responses to vaccinia virus envelope proteins
  20. Human CD8 + cytotoxic T cell responses to adenovirus capsid proteins