Philadelphia University + Thomas Jefferson University

Paumet, Fabienne

< Back

Profile

fmp004

Fabienne Paumet, PhD

Contact Dr. Paumet

233 South Tenth Street
Bluemle Life Sciences Building Room 750
Philadelphia, PA 19107

(215) 503-8567

Research and Clinical Interests

MOLECULAR MECHANISMS OF PHAGOCYTOSIS: HOW DO PATHOGENS SUBVERT THIS PROCESS?
*Unraveling membrane trafficking involved in the phagocytic pathway and its regulation
*How do intracellular bacteria interfere with the host phagocytic system to escape lysosomal degradation?

DO INTRACELLULAR BACTERIA COMMONLY USE SNARE-LIKE PROTEINS TO MANIPULATE THE HOST MEMBRANE FUSION?
*Screening Salmonella and Legionella genomes
*Study the inhibitory effect of potential SNARE-like bacterial proteins

CHARACTERIZATION OF EUKARYOTIC MEMBRANE FUSION MACHINERY
*Identification and characterization of primitive membrane fusion machineries (similar to SNARE proteins)
*Characterization of the specificity of fusion encoded in the SNARE proteins
*Characterization of intramolecular SNARE regulation

STUDY OF THE PHAGOCYTIC MECHANISM IN MAST CELLS, ONE OF THE MAIN PLAYERS IN ALLERGY

Publications

Most Recent Peer-Reviewed Publications

  1. Chlamydia hijacks ARF GTPases to coordinate microtubule posttranslational modifications and golgi complex positioning
  2. A functional core of IncA is required for Chlamydia trachomatis inclusion fusion
  3. An ╬▒-helical core encodes the dual functions of the chlamydial protein IncA
  4. Escherichia coli exposure inhibits exocytic SNARE-mediated membrane fusion in mast cells
  5. Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval Strongyloides stercoralis
  6. Two Coiled-Coil Domains of Chlamydia trachomatis IncA Affect Membrane Fusion Events during Infection
  7. A Novel Function for SNAP29 (Synaptosomal-Associated Protein of 29 kDa) in Mast Cell Phagocytosis
  8. The impact of bacterial infection on mast cell degranulation
  9. SNARE motif: A common motif used by pathogens to manipulate membrane fusion
  10. Intracellular bacteria encode inhibitory SNARE-like proteins
  11. SNARE protein mimicry by an intracellular bacterium
  12. Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
  13. Concerted auto-regulation in yeast endosomal t-SNAREs
  14. The specificity of SNARE-dependent fusion encoded in the SNARE motif
  15. i-SNAREs: Inhibitory SNAREs that fine-tune the specificity of membrane fusion
  16. Cell fusion | La fusion cellulaire
  17. SNAREs and associated regulators in the control of exocytosis in the RBL-2H3 mast cell line
  18. Mechanisms of membrane fusion | M├ęcanisme de la fusion membranaire
  19. A t-SNARE of the endocytic pathway must be activated for fusion
  20. Compartmental specificity of cellular membrane fusion encoded in snare proteins topological restriction of SNARE-dependent membrane fusion: Topological restriction of SNARE-dependent membrane fusion