Philadelphia University + Thomas Jefferson University

Enomoto-Iwamoto, Motomi

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Motomi Enomoto-Iwamoto, PhD, DDS

Contact Dr. Enomoto-Iwamoto

1015 Walnut Street
Curtis 501
Philadelphia, PA 19107

(215) 955-7624
(215) 955-9159 fax

Medical School

DDS, Osaka University - 1983
PhD, Osaka University, Biochemistry - 1987

Expertise and Research Interests

My research interests are to determine the regulatory mechanism of cartilage development, especially endochondral ossification and to understand pathogenesis of joint diseases such as osteoarthritis. Recently we are focusing on Wnt signaling, which exerts critical roles in a variety of biological processes. We have demonstrated that a major Wnt pathway, beta-catenin-LEF/TCF dependent signaling is essential for progression of chondrocyte maturation during skeletal formation. Now we are investigating 1) how this signaling regulates cartilage matrix turn-over and its replacement to bone, 2) how this signaling interacts with other important pathways including retionid and BMP signaling and 3) whether this signaling is involved in pathological degeneration of articular cartilage in joints. We are also interesting in regulation of cytoskeletal structures of chondrocytes. We have found that Rac-1, a small GTPase protein plays important roles in regulation of cell shape and function in chondrocytes. We are now studying on upstream and downstream of Rac-1 proteins.

Keywords

Cartilage; chondrocyte; Wnt; beta-catenin; endochondral ossification; osteoarthritis; small GTPase

Publications

Most Recent Peer-Reviewed Publications

  1. Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs
  2. Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation
  3. Cell therapy for the degenerating intervertebral disc
  4. Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis
  5. EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation
  6. Intervertebral disc development and disease-related genetic polymorphisms
  7. Alpha 5 integrin mediates osteoarthritic changes in mouse knee joints
  8. Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles tendon injury model
  9. Wnt signaling in cartilage development and diseases: Lessons from animal studies
  10. Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg
  11. IL-1β irreversibly inhibits tenogenic differentiation and alters metabolism in injured tendon-derived progenitor cells in vitro
  12. Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: A mechanism possibly involved in hereditary multiple exostoses
  13. The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented in Hereditary Multiple Exostoses: Insights into pathogenesis
  14. Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin
  15. Resident mesenchymal progenitors of articular cartilage
  16. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model
  17. Distribution of slow-cycling cells in epiphyseal cartilage and requirement of β-catenin signaling for their maintenance in growth plate
  18. Tendon progenitor cells in injured tendons have strong chondrogenic potential: The cd105-negative subpopulation induces chondrogenic degeneration
  19. Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through β-catenin-dependent and -independent pathways
  20. Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice