Philadelphia University + Thomas Jefferson University

Eisenman, Leonard M.

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Leonard M. Eisenman, PhD

Contact Dr. Eisenman

1020 Locust Street
Jefferson Alumni Hall, Suite 522
Philadelphia, PA 19107

(215) 503-1686

Medical School

PhD, Duke University - 1974

University Appointment

Professor

Research and Clinical Interests

Structure and function of the cerebellum

The histological organization of the cerebellum is relatively uniform throughout. Given that what distinguishes the different part of the cerebellum and how are those differences related to its function?

In an attempt to address this question my lab has examined the organization of afferents to the cerebellum and the relationship of those afferents to molecular heterogeneities that are characteristic of the cells within the cerebellum. These studies have been done in adult rodents and also in developing and mutant animals whose cerebella are malformed. This enables us to determine what cellular and synaptic relationships are critical in the development of the adult pattern. More recently we have been interested is the relationship between activation cellular patterns within the cerebellum that result from different stimuli, such as alcohol or vestibular stimulation and how these relate to the molecular heterogeneities that have been elucidated within the cerebellum.

We use different neuroanatomical approaches including different neuroanatomical tracers that are transported in an anterograde and/or retrograde fashion, immunohistochemistry, surgical interventions in the brain and spinal cord and behavioral approaches.

I hope that my findings will be used to determine the function of the exquisite molecular and anatomical heterogeneities that are characteristic of the cerebellum and how these differences to function, i.e what do different parts of the cerebellum do. In addition we would also like to determine how these heterogeneities relate to genetic and environmental insults that result in abnormal development and in malfunction of the cerebellum to produce abnormal motor behavior and/or deficits in cognition.

Publications

Most Recent Peer-Reviewed Publications

  1. Ethanol and vestibular stimulation reveal simple and complex aspects of cerebellar heterogeneity
  2. Purkinje cell compartmentation of the cerebellum of microchiropteran bats
  3. Motion sickness may be caused by a neurohumoral action of acetylcholine
  4. Compartmentation of the reeler cerebellum: Segregation and overlap of spinocerebellar and secondary vestibulocerebellar fibers and their target cells
  5. The ventral uvula of the mouse cerebellum: A neural target of ethanol and vestibular stimuli
  6. An absence of tinnitus
  7. Acute ethanol administration produces specific patterns of localization of Fos-immunoreactivity in the cerebellum and inferior olive of two inbred strains of mice
  8. Alcohol differentially affects c-Fos expression in the supraoptic nucleus of long-sleep and short-sleep mice
  9. Antero-posterior boundaries and compartments in the cerebellum: Evidence from selected neurological mutants
  10. Inferior olivary-induced expression of Fos-like immunoreactivity in the cerebellar nuclei of wild-type and Lurcher mice
  11. Neonatal Borna disease virus infection in the rat causes a loss of Purkinje cells in the cerebellum
  12. Regionalization defects in the weaver mouse cerebellum
  13. Rostral cerebellar malformation (rcm/rcm): A murine mutant to study regionalization of the cerebellum
  14. Stripes and zones: The origins of regionalization of the adult cerebellum
  15. A genetic animal model of human neocortical heterotopia associated with seizures
  16. Correspondence between L7-lacZ-expressing Purkinje cells and labeled olivocerebellar fibers during late embryogenesis in the mouse
  17. Developmental analysis of GFAP immunoreactivity in the cerebellum of the meander tail mutant mouse
  18. Morphological correlates of bilateral synchrony in the rat cerebellar cortex
  19. Further evidence for a unique developmental compartment in the cerebellum of the meander tail mutant mouse as revealed by the quantitative analysis of Purkinje cells
  20. Development of the spinocerebellar projection in the prenatal mouse