Philadelphia University + Thomas Jefferson University

Eischen, Christine

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Christine Eischen, PhD

Christine Eischen, PhD

Contact Dr. Eischen

233 South 10th Street
BLSB 650
Philadelphia, PA 19107

(215) 503-5262

Research & Clinical Interests

The focus of the Eischen laboratory is to identify and study the genes that regulate cellular transformation.  This is accomplished through approaches designed to test how specific genes impact cell proliferation, apoptosis, chromosomal stability, and DNA repair.  We utilize mice and cell lines that lack or overexpress one or more genes and mice that are genetically engineered to spontaneously develop cancers.  We also utilize patient samples. A large part of the laboratory studies B cell lymphoma, but there are also projects on carcinoma of the lung, breast, and ovary.  Many of the genes we study are revealed to influence known oncogenic and tumor suppressor pathways linked to cancer.  Currently, there are ongoing investigations into the genes that regulate or contribute to the oncogenic functions of Myc, Mdm2, and Ras and the tumor suppressor functions of Arf and p53. Studies to evaluate the role of specific miRNA in cellular transformation are also being performed. Our goal is to determine the function of novel genes/RNA or discover a new function for a known gene/RNA that increases understanding into tumorigenesis. Our research should also identify potential therapeutic targets that could lead to improved intervention strategies for the treatment of human malignancies. 

Publications

Most Recent Peer-Reviewed Publications

  1. Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition
  2. Mdm2 is required for survival and growth of p53-deficient cancer cells
  3. Defective replication stress response inhibits lymphomagenesis and impairs lymphocyte reconstitution
  4. Role of Mdm2 and Mdmx in DNA repair
  5. BCL-W has a fundamental role in B cell survival and lymphomagenesis
  6. The potential roles of long noncoding RNAs (lncRNA) in glioblastoma development
  7. TOX expression and role in CTCL
  8. Molecular underpinnings of HDAC inhibition revealed
  9. Histone deacetylase inhibition reveals a tumor-suppressive function of MYC-regulated miRNA in breast and lung carcinoma
  10. Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif
  11. Genome stability requires p53
  12. miR-31 and miR-17-5p levels change during transformation of follicular lymphoma
  13. Myc Induces miRNA-mediated apoptosis in response to HDAC inhibition in hematologic malignancies
  14. MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer
  15. Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice
  16. Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer
  17. SMARCAL1 maintains telomere integrity during DNA replication
  18. Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model
  19. Pharmacologically increasing Mdm2 inhibits DNA repair and cooperates with genotoxic agents to kill p53-inactivated ovarian cancer cells
  20. Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides