Adam P. Dicker, MD, PhD, FASTRO
Room G-301, Bodine Center
Philadelphia, PA 19107
(215) 503-0013 fax
Research & Clinical Interest
My mission, “Empowering patients through translational cancer research."
As Chair & Professor of Radiation Oncology, Pharmacology and Experimental Therapeutics at Thomas Jefferson University, I coordinate an interdisciplinary team of oncologists, physicists and scientists focused on multidisciplinary effort to define fundamental mechanisms and targets for combined modality radiation treatment and efficiently translate them to effective innovations in treating cancer patients.
Our group defined for prostate brachytherapy the influence of edema on dosimetric parameters critical for quality metrics, with more recent research correlating radiotherapy protocol deviations and overall survival (JNCI, 2012). In 2013 I was appointed to the American Society for Radiation Oncology (ASTRO) Radiation Oncology Healthcare Advisory Council for the Radiation Oncology Incident Learning System (PSO) as part of a nationwide effort to improve safety and quality.
Our work funded by the Department of Defense (DoD) and the Prostate Cancer Foundation focuses on the “self-seeding” of prostate cells with metastatic properties back to the site of origin, contributing to disease progression. I am the PI of a DoD Prostate Synergy Grant, exploring the use of “smart needles” for diagnostic and therapeutic applications. We have published numerous papers evaluating signal transduction agents with ionizing radiation and published “first in human” developmental therapeutic trials involving novel signal transduction agents and radiation therapy.
I serve as the co-Chair-Translational Science Committee for the NCI cooperative group, NRG Oncology recently awarded a U10 for an Integrated Translational Genoproteomics Center at Washington University. The long-term objective is to enable delivery of deep tumor ‘omic analysis results to cooperative group investigators for clinical trial screening, eligibility and pharmacodynamic studies of drug action to provide maximal impact in translational medicine. I have approval authority for the translational research across all solid tumors sites with a particular emphasis on predictive biomarkers, preclinical research, and molecular signatures. Through a team effort, I coordinated the creation of a NCI–RTOG Translational Program Strategic Guidelines for the Early-Stage Development of Radiosensitizers (JNCI, 2013). I serve on the Clinical, Translational, and Basic Science Advisory Committee of ASTRO and am past Chair of the Radiation and Cancer Biology Committee. In 2014, I was selected as a Fellow of ASTRO designation (FASTRO), for contributions to the field of radiation oncology in the areas of research, education, patient care, service, and leadership.
I represent the NRG Oncology on the National Cancer Institute’s Investigational Drug Steering Committee of CTEP and am a consultant on Cancer to the European Commission, the National Cancer Institute of Canada and the Italian Association of Cancer Research. I was recently appointed as a member of the Integration Panel for the Prostate Cancer Research Program of the DoD. I have supervised over 40 Residents who worked with me on my clinical service. Many of my trainees are early and mid-career clinician researchers and clinician-scientists in academic medicine here and abroad.
I have experience in clinical care, quality assurance & patient safety, prostate cancer, clinical trials, facilitating RTOG/NRG Oncology investigator research, drug development, entrepreneurship, preclinical model systems, biomarker analysis, and mentorship.
Most Recent Peer-Reviewed Publications
- Ensuring sample quality for blood biomarker studies in clinical trials: A multicenter international study for plasma and serum sample preparation
- Randomized Phase II Study of Preoperative Chemoradiotherapy ± Panitumumab Followed by Consolidation Chemotherapy in Potentially Operable Locally Advanced (Stage IIIa, N2+) Non–Small Cell Lung Cancer: NRG Oncology RTOG 0839
- Phase 1 Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma Patients With Brain Metastases
- IGFBP3 modulates lung tumorigenesis and cell growth through IGF1 signaling
- A phase II randomized trial of Observation versus stereotactic ablative RadiatIon for OLigometastatic prostate CancEr (ORIOLE)
- Genomic classifier augments the role of pathological features in identifying optimal candidates for adjuvant radiation therapy in patients with prostate cancer: Development and internal validation of a multivariable prognostic model
- Individual patient-level meta-Analysis of the performance of the decipher genomic classifier in high-risk men after prostatectomy to predict development of metastatic disease
- Comparison of Online 6 Degree-of-Freedom Image Registration of Varian TrueBeam Cone-Beam CT and BrainLab ExacTrac X-Ray for Intracranial Radiosurgery
- Cost-effectiveness of the Decipher Genomic Classifier to Guide Individualized Decisions for Early Radiation Therapy After Prostatectomy for Prostate Cancer
- RB loss promotes prostate cancer metastasis
- Reaffirming and clarifying the American Society of Clinical Oncology's policy statement on the critical role of phase i trials in cancer research and treatment
- Expression of the DNA repair gene MLH1 correlates with survival in patients who have resected pancreatic cancer and have received adjuvant chemoradiation: NRG Oncology RTOG Study 9704
- Hematologic Toxicity of Concurrent Administration of Radium-223 and Next-generation Antiandrogen Therapies
- Molecular Analysis of Low Grade Prostate Cancer Using a Genomic Classifier of Metastatic Potential
- Dosimetric validation for an automatic brain metastases planning software using single-isocenter dynamic conformal arcsDosimetric validation for an automatic brain metastases planning software using single-isocenter dynamic conformal arcs
- Patient-level DNA damage and repair pathway profiles and prognosis after prostatectomy for high-risk prostate cancer
- Closed loop control of a robot assisted smart flexible needle for percutaneous intervention
- Reply to C.G. Rusthoven et al
- Is robotic arm stereotactic body radiation therapy 'virtual high-dose rate brachytherapy' effective for prostate cancer? An analysis of comparative effectiveness using published data
- Evaluating the clinical impact of a genomic classifier in prostate cancer using individualized decision analysis