Philadelphia University + Thomas Jefferson University

Cingolani, Gino

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Gino Cingolani, PhD

Contact Dr. Cingolani

233 South 10th Street
BLSB Room 826
Philadelphia, PA 19107

(215) 503-4573
(215) 923-2117 fax

Research and Clinical Interests

Molecular cell biology of Nucleocytoplasmic Transport; X-ray crystallography and biophysical analysis of viral DNA-pumping machinery; structure of multi-subunit ATP synthases.

My laboratory uses X-ray crystallography, combined with biophysical and biochemical techniques to probe the structure and function of large macromolecular machines. We are interested in a variety of biological problems, which include the mechanisms and regulation of nucleocytoplasmic transport, the delivery of viral DNA into living cells, and the structure and regulation of multi-subunit ATP synthases. Our structural approach provides a unique tool to understand the function and engineer the activity of biological molecules. Visit our website (http://www.cingolanilab.org/) for more info.

Publications

Most Recent Peer-Reviewed Publications

  1. Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
  2. Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms
  3. Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation
  4. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
  5. Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)
  6. Divergent evolution of nuclear localization signal sequences in herpesvirus terminase subunits
  7. Structural plasticity of the protein plug that traps newly packaged genomes in podoviridae virions
  8. PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage
  9. Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22
  10. A greasy aid to capsid assembly: Lessons from a salty virus
  11. Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins
  12. The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD
  13. Structure-based screen identifies a potent small molecule inhibitor of Stat5a/b with therapeutic potential for prostate cancer and chronic myeloid leukemia
  14. IPO3-mediated nonclassical nuclear import of NF-κB essential modulator (NEMO) drives DNA damage-dependent NF-κB activation
  15. Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2
  16. Dimeric quaternary structure of human laforin
  17. Diversification of importin-α isoforms in cellular trafficking and
  18. Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7
  19. Structure of human PIR1, an atypical dual-specificity phosphatase
  20. Jamming up the "β-staple": Regulation of SIRT1 activity by its C-terminal regulatory segment (CTR)